Results 111 to 120 of about 2,909,703 (371)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Comparative Analysis of Chemical Activators and Expansive Agents for Aeolian Sand Stabilization Using Industrial Solid Waste-Based Geopolymers

Gels
Aeolian sand is the primary geological material for construction in desert regions, and its stabilization with industrial solid wastes-based geopolymer (ISWG) provides an eco-friendly treatment replacing cement.
Zilu Xie, Zengzhen Qian, Xianlong Lu, Hao Wang, Phatyoufy Lai   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Automated derivation of stellar atmospheric parameters and chemical abundances: the MATISSE algorithm

, 2006
We present an automated procedure for the derivation of atmospheric parameters (Teff, log g, [M/H]) and individual chemical abundances from stellar spectra.
Bijaoui, A., de Laverny, P., Recio-Blanco, A.   +2 more
core   +3 more sources

Chemical fixation of electroplating sludge and microstructural analysis of stabilised matrix using fly ash and cement

Materials Research Innovations, 2009
AbstractStabilisation and microstructural examination of stabilised electroplating industrial sludge has been studied. Investigations were undertaken to formulate cementitous binder by judicious blending of fly ash, sludge and cement with five mix proportions. The major metallic contaminants were cadmium, chromium, copper, nickel and lead.
Dayananda, H. S., Lokesh, K. S., Byrappa, K.   +2 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Density-matrix renormalization study of the frustrated fermions on the triangular lattice

, 2009
We show that the two-dimensional density-matrix renormalization analysis is useful to detect the symmetry breaking in the fermionic model on a triangular lattice.
Hotta, C., Nishimoto, S.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Compositional data analysis in archaeometry [PDF]

, 2003
We shall call an n × p data matrix fully-compositional if the rows sum to a constant, and sub-compositional if the variables are a subset of a fully-compositional data set1.
Baxter, MJ, Beardah, CC, Cool, HEM, Jackson, CM   +3 more
core   +1 more source

Physicochemical properties of new cellulosic fiber extracted from Carica papaya bark

Journal of Natural Fibers, 2019
This article presents the characteristics of Carica papaya fibers (CPFs) extracted from the bark of the perennial papaya plant. Detailed chemical compositions of CPFs such as cellulose, lignin, ash, moisture, and wax contents were established and ...
A Saravana Kumaar, A Senthilkumar, T Sornakumar, S.S Saravanakumar, V.P Arthanariesewaran   +4 more
doaj   +1 more source