Results 131 to 140 of about 2,909,703 (371)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

PD38-05 A NEW METHOD OF MULTIFACETED STRUCTURE ANALYSIS: TWO-DIMENSIONAL MAPS OF “CHEMICAL ELEMENTS” AND “MATRIX PROTEIN” IN CALCIUM-CONTAINING STONES [PDF]

, 2019
Yutaro Tanaka, Atsushi Okada, Mihoko Maruyama, Teruaki Sugino, Rei Unno, Kazumi Taguchi, Shuzo Hamamoto, Ryosuke Ando, Masashi Yoshimura, Yusuke Mori, Kenjiro Kohri, Takahiro Yasui   +11 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Investigation of the deterioration of blended cement concrete under sulfate attack in terms of interfacial transition zone

, 2017
The importance of the porous interfacial transition zone to the chemical aggression of concrete is obvious when one considers the relations existing between porosity, permeability, chemical composition and the sulfate attack. In this study, the effect of
De Schutter, Geert, Gao, Yun, Shi, Huisheng, Wu, Kai, Ye, Guang   +4 more
core  

Studying the specific features of the hydration processes of alumina cements based on the compounds of CaO–NiO–Al₂O₃ system [PDF]

, 2018
The article gives the results of studying hydration processes occurring in cement synthesis using waste products of chemical industry. Cement clinker was synthesized with the relation of initial raw components, calcium-containing water treatment waste ...
Khrystych, E. V., Korogodska, A. M., Shabanova, G. M., Shutynskyy, O. G., Tsapko, N. S., Vorozhbiyan, R. M.   +5 more
core  

Technical note: Chemical composition and source identification of fluorescent components in atmospheric water-soluble brown carbon by excitation–emission matrix spectroscopy with parallel factor analysis – potential limitations and applications [PDF]

, 2023
Tao Cao, Meiju Li, Cuncun Xu, Jianzhong Song, Xingjun Fan, Jun Li, Wanglu Jia, Ping’an Peng   +7 more
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

CHEMICAL AND MORPHOLOGICAL EFFECTS OF POLYURETHANE AND LIQUID SILICONE RUBBER ON EPOXY COMPOSITES

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
This study aimed to improve the morphological properties of Sikadur 52 epoxy resin by incorporating polyurethane (PU) and liquid silicone rubber (LSR) as toughening agents.
Roaa Mohammed Muneer
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source