Results 91 to 100 of about 1,429,804 (373)

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

A new operational matrix based on Bernoulli polynomials [PDF]

, 2014
In this research, the Bernoulli polynomials are introduced. The properties of these polynomials are employed to construct the operational matrices of integration together with the derivative and product.
Kazem, S., Parand, K., Rad, J. A., Shaban, M.   +3 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Hill's Equation with Random Forcing Parameters: The Limit of Delta Function Barriers

, 2009
This paper considers random Hill's equations in the limit where the periodic forcing function becomes a Dirac delta function. For this class of equations, the forcing strength $q_k$, the oscillation frequency $\af_k$, and the period are allowed to vary ...
Abramowitz M., Anthony M. Bloch, Binney J., Fred C. Adams, Kolb E. W., Magnus W., Pastur L.   +6 more
core   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

Molecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause, Rixa‐Mareike Köhn, Christian Ickes, Julia Lenger, Jonas Fischer, Sabrina Cappello, Ivan Bogeski   +6 more
wiley   +1 more source

A Liapunov functional for a matrix difference-differential equation

Journal of Differential Equations, 1978
AbstractA quadratic positive definite functional that yields necessary and sufficient conditions for the asymptotic stability of the solutions of the matrix difference-differential equation ẋ(t) = Ax(t) + Bx(t − τ) is constructed and its structure is analyzed. This functional, a Liapunov functional, provides the best possible estimate for the rates of
W.B Castelan, W.B Castelan, E.F Infante
openaire   +3 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

New Analytical Approach for Computation of Band Structure in One-dimensional Periodic Media

, 2003
In this paper, we present a new approach for the exact calculation of band structure in one-dimensional periodic media, such as photonic crystals and superlattices, based on the recently reported differential transfer matrix method (DTMM).
Abdulhalim, Abdulhami, Ali Adibi, Axmann, Brillouin, Chigrin, Davison, Felbacq, Fink, Hall, Jeong, Joannopoulos, Kelly, Khorasani, Khorasani, Liu, Lusk, Mehrany, Mladenov, Moler, Nefedov, Russel, Sina Khorasani, Yariv, Yeh, Zhu   +25 more
core   +1 more source

Oscillation criteria for nonlinear matrix differential equations [PDF]

Proceedings of the American Mathematical Society, 1970
Oscillation criteria are established for nonlinear matrix differential equations of the form [ R ( t ) U ′ ] ′ + F ( t , U , U ′ ) = 0 [R(t)U’]’ + F(t,U,U’)
openaire   +3 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source