Results 51 to 60 of about 815,798 (337)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Nonlinear boudary value problem in the case of parametric resonance [PDF]

Компьютерные исследования и моделирование, 2015
We construct necessary and sufficient conditions for the existence of solution of seminonlinear matrix boundary value problem for a parametric excitation system of ordinary differential equations.
Sergey Mikhaylovich Chujko, O. V. Nesmelova (Starkova), D. V. Sysoev   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

An integral equation based numerical solution for nanoparticles illuminated with collimated and focused light [PDF]

, 2009
To address the large number of parameters involved in nanooptical problems, a more efficient computational method is necessary. An integral equation based numerical solution is developed when the particles are illuminated with collimated and focused ...
Challener, Glisson, Grosges, Harrington, Hartschuh, Jung, Kottmann, Kottmann, Kottmann, Kottmann, Kursat Sendur, Lewis, Liedberg, Liu, McDaniel, Milster, Pohl, Rao, Richards, Richmond, Rottmayer, Sendur, Wang, Wilton, Wolf, Yamaguchi, Yamaguchi   +26 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Stability of delay differential equations via delayed matrix sine and cosine of polynomial degrees

Advances in Difference Equations, 2017
In this paper, we study the finite time stability of delay differential equations via a delayed matrix cosine and sine of polynomial degrees. Firstly, we give two alternative formulas of the solutions for a delay linear differential equation.
Chengbin Liang, Wei Wei, JinRong Wang
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Matrix Methods for Solving Hartree-Fock Equations in Atomic Structure Calculations and Line Broadening

Atoms, 2018
Atomic structure of N-electron atoms is often determined by solving the Hartree-Fock equations, which are a set of integro-differential equations. The integral part of the Hartree-Fock equations treats electron exchange, but the Hartree-Fock equations ...
Thomas Gomez, Taisuke Nagayama, Chris Fontes, Dave Kilcrease, Stephanie Hansen, Mike Montgomery, Don Winget   +6 more
doaj   +1 more source

Existence of a Unique Solution and the Hyers–Ulam-H-Fox Stability of the Conformable Fractional Differential Equation by Matrix-Valued Fuzzy Controllers

Complexity, 2022
In this paper, we consider a conformable fractional differential equation with a constant coefficient and obtain an approximation for this equation using the Radu–Mihet method, which is derived from the alternative fixed- point theorem.
Zahra Eidinejad, Reza Saadati, Tofigh Allahviranloo, Farzad Kiani, Samad Noeiaghdam, Unai Fernandez-Gamiz   +5 more
doaj   +1 more source

Physics-Informed Neural Networks and Functional Interpolation for Solving the Matrix Differential Riccati Equation

Mathematics, 2023
In this manuscript, we explore how the solution of the matrix differential Riccati equation (MDRE) can be computed with the Extreme Theory of Functional Connections (X-TFC). X-TFC is a physics-informed neural network that uses functional interpolation to
Kristofer Drozd, Roberto Furfaro, Enrico Schiassi, Andrea D’Ambrosio   +3 more
doaj   +1 more source