Results 81 to 90 of about 815,798 (337)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Perturbation analysis of a matrix differential equation $\dot x=ABx$
, 2018 Two complex matrix pairs $(A,B)$ and $(A',B')$ are contragrediently equivalent if there are nonsingular $S$ and $R$ such that $(A',B')=(S^{-1}AR,R^{-1}BS)$. M.I. Garc\'{\i}a-Planas and V.V.
Garcìa-Planas, M. Isabel +1 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Oscillation criteria for nonlinear matrix differential equations [PDF]
Proceedings of the American Mathematical Society, 1970 Oscillation criteria are established for nonlinear matrix differential equations of the form [ R ( t ) U ′ ] ′ + F ( t , U , U ′ ) = 0 [R(t)U’]’ + F(t,U,U’)
openaire +2 more sources
Hill's Equation with Random Forcing Parameters: The Limit of Delta Function Barriers
, 2009 This paper considers random Hill's equations in the limit where the periodic forcing function becomes a Dirac delta function. For this class of equations, the forcing strength $q_k$, the oscillation frequency $\af_k$, and the period are allowed to vary ...
Abramowitz M. +6 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
New Analytical Approach for Computation of Band Structure in One-dimensional Periodic Media
, 2003 In this paper, we present a new approach for the exact calculation of band structure in one-dimensional periodic media, such as photonic crystals and superlattices, based on the recently reported differential transfer matrix method (DTMM).
Abdulhalim +25 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
R-matrix for a geodesic flow associated with a new integrable peakon equation
, 2016 We use the r-matrix formulation to show the integrability of geodesic flow on an $N$-dimensional space with coordinates $q_k$, with $k=1,...,N$, equipped with the co-metric $g^{ij}=e^{-|q_i-q_j|}\big(2-e^{-|q_i-q_j|}\big)$.
Holm, Darryl D., Qiao, Zhijun
core
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source