Results 141 to 150 of about 13,801,421 (357)
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
The sharp square function estimate with matrix weight
Discrete Analysis, 2019 The sharp square function estimate with matrix weight, Discrete Analysis 2019:2, 8 pp. A central theme in harmonic analysis is to determine whether naturally occurring operators are bounded with respect to naturally occurring norms.
Tuomas Hytönen +2 more
doaj +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Systems of Partial Differential Equations for Hypergeometric Functions of Matrix Argument [PDF]
, 1970 Robb J. Muirhead
openalex +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
The Fuglede commutativity theorem modulo the Hilbert-Schmidt class and generating functions for matrix operators. I [PDF]
, 1978 Gary M. Weiss
openalex +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Certain Results on Extended Beta and Related Functions Using Matrix Arguments
Journal of New TheoryIn this study, we present and explore extended beta matrix functions (EBMFs) and their key properties. By utilizing the beta matrix function (BMF), we introduce novel extensions of the Gauss hypergeometric matrix function (GHMF) and Kummer hypergeometric
Saddam Husain +2 more
doaj +1 more source