Results 141 to 150 of about 4,588,425 (332)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Kinematic Mapping in Semi-Euclidean 4-Space
Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2014 We study the some algebraic properties of matrix associated to Hamilton operators is defined for semi-quaternions. The kinematic mapping corresponding to these operators in semi-Euclidean 4-space is same as the kinematic mapping of Blaschke and Grünwald ...
Mehdi JAFARI
doaj
Application Level Synthesis: Creating Matrix-Matrix Multiplication Library: A Case Study
IEEE AccessEfficiently synthesizing an entire application that consists of multiple algorithms for hardware implementation is a very difficult and unsolved problem. One of the main challenges is the lack of good algorithmic libraries.
Dhilleswararao Pudi +6 more
doaj +1 more source
Atomic Positive Linear Maps in Matrix Algebras
Publications of the Research Institute for Mathematical Sciences, 1998 We show that all of the known generalizations of the Choi maps are atomic maps.
openaire +3 more sources
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
A multi-strategy ontology mapping method based on cost-sensitive SVM
Journal of Cloud Computing: Advances, Systems and ApplicationsAs the core of ontology integration, the task of ontology mapping is to find the semantic relationship between ontologies. Nevertheless, most existing ontology mapping methods only rely ontext information to calculate entity similarity, thereby ...
Fan Zhang +6 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source