Results 51 to 60 of about 386,457 (283)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

On distance signless Laplacian eigenvalues of zero divisor graph of commutative rings

open access: yesAIMS Mathematics, 2022
For a simple connected graph $ G $ of order $ n $, the distance signless Laplacian matrix is defined by $ D^{Q}(G) = D(G) + Tr(G) $, where $ D(G) $ and $ Tr(G) $ is the distance matrix and the diagonal matrix of vertex transmission degrees, respectively.
Bilal A. Rather   +4 more
doaj   +1 more source

Leavitt path algebras: Graded direct-finiteness and graded $\Sigma$-injective simple modules

open access: yes, 2017
In this paper, we give a complete characterization of Leavitt path algebras which are graded $\Sigma $-$V$ rings, that is, rings over which a direct sum of arbitrary copies of any graded simple module is graded injective.
Hazrat, Roozbeh   +2 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Vibration analysis of rotating rings with complex support stiffnesses

open access: yesMATEC Web of Conferences, 2018
Vibration characteristics of rotating rings with complex support stiffnesses are studied. The complex stiffnesses of the rotating ring include discrete stiffnesses and partially distributed stiffnesses. The governing equations are established by Hamilton’
Yang Fuchun, Zhang Yue, Li Hailong
doaj   +1 more source

Perturbations of vortex ring pairs

open access: yes, 2015
We study pairs of co-axial vortex rings starting from the action for a classical bosonic string in a three-form background. We complete earlier work on the phase diagram of classical orbits by explicitly considering the case where the circulations of the
Gubser, Steven S.   +2 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Tripotents: a class of strongly clean elements in rings

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2018
Periodic elements in a ring generate special classes of strongly clean elements. In particular, elements b such that b = b3+, which are called tripotents and include idempotents, negative of idempotents and order 2 units, are strongly clean.
Călugăreanu Grigore
doaj   +1 more source

Vehicle–track–tunnel dynamic interaction: a finite/infinite element modelling method

open access: yesRailway Engineering Science, 2021
The aim of this study is to develop coupled matrix formulations to characterize the dynamic interaction between the vehicle, track, and tunnel. The vehicle–track coupled system is established in light of vehicle–track coupled dynamics theory.
Lei Xu, Wanming Zhai
doaj   +1 more source

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