Results 61 to 70 of about 386,457 (283)
Semigroup Forum, 1993 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Multiplicative maps on generalized \(n\)-matrix rings
CuboLet \(\mathfrak{R}\) and \(\mathfrak{R}'\) be two associative rings (not necessarily with identity elements). A bijective map \(\varphi\) of \(\mathfrak{R}\) onto \(\mathfrak{R}'\) is called an \textit{\(m\)-multiplicative isomorphism} if {\(\varphi (x_ ...
Aisha Jabeen, Bruno L. M. Ferreira
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Jordan left derivations in infinite matrix rings
Demonstratio MathematicaLet RR be a unital associative ring. Our motivation is to prove that left derivations in column finite matrix rings over RR are equal to zero and demonstrate that a left derivation d:T→Td:{\mathcal{T}}\to {\mathcal{T}} in the infinite upper triangular ...
Zhang Daochang +3 more
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Gorenstein Projective Modules Over Triangular Matrix Rings [PDF]
, 2014 We study totally acyclic complexes of projective modules over triangular matrix rings and then use it to classify Gorenstein projective modules over such rings.
Eshraghi, Hossein +3 more
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source