Results 61 to 70 of about 379,307 (280)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Multiplicative maps on generalized \(n\)-matrix rings
CuboLet \(\mathfrak{R}\) and \(\mathfrak{R}'\) be two associative rings (not necessarily with identity elements). A bijective map \(\varphi\) of \(\mathfrak{R}\) onto \(\mathfrak{R}'\) is called an \textit{\(m\)-multiplicative isomorphism} if {\(\varphi (x_ ...
Aisha Jabeen, Bruno L. M. Ferreira
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Gorenstein Projective Modules Over Triangular Matrix Rings [PDF]
, 2014 We study totally acyclic complexes of projective modules over triangular matrix rings and then use it to classify Gorenstein projective modules over such rings.
Eshraghi, Hossein +3 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Jordan left derivations in infinite matrix rings
Demonstratio MathematicaLet RR be a unital associative ring. Our motivation is to prove that left derivations in column finite matrix rings over RR are equal to zero and demonstrate that a left derivation d:T→Td:{\mathcal{T}}\to {\mathcal{T}} in the infinite upper triangular ...
Zhang Daochang +3 more
doaj +1 more source
International Journal of Mathematics and Mathematical Sciences, 2003 We introduce the notion of clean ideal, which is a natural generalization of clean rings. It is shown that every matrix ideal over a clean ideal of a ring is clean. Also we prove that every ideal having stable range one of a regular ring is clean.
Huanyin Chen, Miaosen Chen
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Karpatsʹkì Matematičnì Publìkacìï, 2018 We investigate commutative Bezout domains in which any nonzero prime ideal is contained in a finite set of maximal ideals. In particular, we have described the class of such rings, which are elementary divisor rings.
B.V. Zabavsky, O.M. Romaniv
doaj +1 more source