Results 81 to 90 of about 386,457 (283)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Semi-neat rings: A generalization of neat ring structures

AIMS Mathematics
This article introduces the concept of semi-neat rings, a generalization of neat rings, defined as rings whose nontrivial homomorphic images are semiclean.
Abdallah A. Abukeshek, Andrew Rajah
doaj   +1 more source

Strong primeness in matrix rings

Journal of Algebra, 2014
A ring \(R\) is right strongly prime if for every nonzero \(a\in R\), there exists a nonempty finite subset \(S\) of \(R\) (called a right insulator for \(a\)) such that the set \(aS\) has a trivial right annihilator. A ring \(R\) is right strongly prime of bound \(n\) if there exists a positive integer \(n\) such that every nonzero element in \(R ...
Thackeray, Henry (Maya) Robert, Van den Berg, J.E. (John)   +1 more
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Modelling of rotations by using matrix solutions of nonlinear wave equations

Mathematical Modelling and Analysis, 2007
A family of matrix solutions of nonlinear wave equations is extended and its application to modelling is given. It is shown that a similarity transformation, induced by the matrix solution, is equivalent to the rotation.
Vladimir Vasilevich Gudkov
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

On Axis-Reversible Rings

Mathematics
This work explores the notion of axis-reversible rings, a generalization of axis-commutative rings. The objective is to investigate their characteristics and relevance within the wider context of ring theory.
Muhammad Saad, Majed Zailaee
doaj   +1 more source

On p.p.-rings which are reduced

International Journal of Mathematics and Mathematical Sciences, 2006
Denote the 2×2 upper triangular matrix rings over ℤ and ℤp by UTM2(ℤ) and UTM2(ℤp), respectively. We prove that if a ring R is a p.p.-ring, then R is reduced if and only if R does not contain any subrings isomorphic to UTM2(ℤ) or UTM2(ℤp).
Xiaojiang Guo, K. P. Shum
doaj   +1 more source