Results 81 to 90 of about 379,307 (280)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On p.p.-rings which are reduced
International Journal of Mathematics and Mathematical Sciences, 2006 Denote the 2×2 upper triangular matrix rings over ℤ and ℤp by UTM2(ℤ) and UTM2(ℤp), respectively. We prove that if a ring R is a p.p.-ring, then R is reduced if and only if R does not contain any subrings isomorphic to UTM2(ℤ) or UTM2(ℤp).
Xiaojiang Guo, K. P. Shum
doaj +1 more source
Strong primeness in matrix rings
Journal of Algebra, 2014 A ring \(R\) is right strongly prime if for every nonzero \(a\in R\), there exists a nonempty finite subset \(S\) of \(R\) (called a right insulator for \(a\)) such that the set \(aS\) has a trivial right annihilator. A ring \(R\) is right strongly prime of bound \(n\) if there exists a positive integer \(n\) such that every nonzero element in \(R ...
Thackeray, Henry (Maya) Robert +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Al-Mustansiriyah Journal of Science, 2019 This paper concerned with the solution of the nanoscale structures consisting of the with an effective mass envelope function theory, the electronic states of the quantum ring are studied.
Eman Ali Hussain +2 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
MathematicsThis work explores the notion of axis-reversible rings, a generalization of axis-commutative rings. The objective is to investigate their characteristics and relevance within the wider context of ring theory.
Muhammad Saad, Majed Zailaee
doaj +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source