Results 111 to 120 of about 329,808 (302)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Variability in mRNA translation: a random matrix theory approach. [PDF]

Sci Rep, 2021
Margaliot M, Huleihel W, Tuller T.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Dynamical quantum phase transitions from random matrix theory [PDF]

Quantum
We uncover a novel dynamical quantum phase transition, using random matrix theory and its associated notion of planar limit. We study it for the isotropic XY Heisenberg spin chain.
David Pérez-García, Leonardo Santilli, Miguel Tierz   +2 more
doaj   +1 more source

Use of random matrix theory in the discovery of resting state brain networks. [PDF]

Magn Reson Imaging, 2021
Bansal R, Peterson BS.
europepmc   +1 more source

Open membranes in matrix theory [PDF]

Physics Letters B, 1997
We discuss how to construct open membranes in the recently proposed matrix model of M theory. In order to sustain an open membrane, two boundary terms are needed in the construction. These boundary terms are available in the system of the longitudinal five-branes and D0-branes.
openaire   +2 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Computational connection matrix theory

, 2019
We develop a computational and categorical framework for connection matrix theory. In terms of computations, we give an algorithm for computing the connection matrix based on algebraic-discrete Morse theory.

core   +1 more source

Dynamic Functional Connectivity Change-Point Detection With Random Matrix Theory Inference. [PDF]

Front Neurosci, 2021
Kim J, Jeong W, Chung CK.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source