Results 91 to 100 of about 10,032,286 (342)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A scientific rationale for consciousness

Substantia, 2019
Consciousness is a concept that can be easily experimented but not easily defined. We show that the same observation applies to information, entropy and even energy.
Marc Henry, Jean-Pierre Gerbaulet
doaj   +1 more source

Organic Matter and Aggregate‐Size Interactions in Saturated Hydraulic Conductivity [PDF]

, 2004
Marcos Lado, Antônio Paz González, M. Ben‐Hur   +2 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Primordial black holes from inflaton and spectator field perturbations in a matter-dominated era [PDF]

, 2017
B. J. Carr, Tommi Tenkanen, Ville Vaskonen   +2 more
openalex   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Space and Matter in the Poetic and Artistic Perception of José Ángel Valente

Castilla: Estudios de Literatura, 2015
The poetry of José Ángel Valente brings up fundamental issues of space and matter, combining the poetic voice with the artistic and philosophical thought.
Ching Yu Lin
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

FRONT MATTER

JINOP (Jurnal Inovasi Pembelajaran), 2018
FRONT MATTER FRONT MATTER
doaj   +3 more sources

My Image of the Unified Knowledge

Интеллект. Инновации. Инвестиции
The knowledge acquired by Mankind does not represent a single whole. Contradictions between religious and philosophical teachings and scientific theories exacerbate the already tense relations that, as a rule, develop between peoples, states and powerful
E. V. Ryltsev
doaj   +1 more source