Results 141 to 150 of about 10,032,286 (342)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Timing of Antitubulin Therapy: Does It Matter? [PDF]

, 2000
Robert B. Livingston
openalex   +1 more source

Why Matters Matter

, 2014
Immanuel Kant said that the character of art consists in making people think. But what thoughts are aroused by works such as Brillo Box or Duchamp’s urinal? The aim of the present essay is to analyse art, and conceptual art in particular, in the light of new realism and documentality, arguing for the contemporary prevalence of works of aura over works ...
openaire   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Signatures of dark matter in cosmic-ray observations

, 2020
Alessandro Cuoco
openalex   +1 more source

Extracts from an Address on College Politics: Matters concerning the Royal College of Surgeons of England [PDF]

, 1888
Patrick Swain
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

JLO volume 109 issue 12 Cover and Back matter [PDF]

, 1995
Lionel Colledge Memorial, Abramovich, See Thomas, Ahluwalia, See Singh, Ahluwalia Ahmad, Jas Carruth, Carruth See Colquhoun-Flannery, See Colquhoun-Flannery, G Caruso, See Barzan, Chagnaud, G Franchin, Fraser, See Rowley, Freche, See Koka, See Freeland, Koay, Gadre Gadre, Gaikwad, See Grewal, Al Gale, See Zidar, See Gallimore, Mcferran, Owa, Gantz, Garcia, See Crevier-Buchman, Gardiner, See Dilkes, Gareth-Williams, See Mills, See Garth, Thomas, Gatot, Gersdorff, See Cao, Gibb Gibb, Gibbin, See Kp, Mason, Gibbin Gibbin, Gibson, J Haapaniemi, F Haddad, See Atiyeh, J-F See Haguet, Koka, Rek Hansen, See Tvinnereim, J Harcourt, Tungekar, Mf, L See Harding, Walsh, P Harkness, P Brown, S Fowler, H Grant, J Topham, M Harries, Harries Spraggs, Harries, Mll, S Lam, C Macaulay, J Qu, B Palcic, P Harries, C Randall, H Harrison, See Gibson, C Leemans, Ajm Balm, R Gregor, Fjm Hilgers, Y Lensky, See Rakover, C Lewis, A Resouly, Ce See Lewis, Koay, Gas See Lloyd, Roberts, B Loftus, See Dijkstra, W Low, J Fenton, P Fagan, Wpr Gibson, S-J Lu, Chang, S-Y Shiao, G-M, Lun Sham, C See, Chi Tong, L Mcclymont   +99 more
openalex   +1 more source