Results 181 to 190 of about 2,996,286 (308)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Impact of physical activity and exercise interventions on white matter integrity in overweight and obese populations: A systematic review and meta-analysis. [PDF]

Compr Psychoneuroendocrinol
Shettigar D, Sukumar S, Kadavigere R, Vaishali K, Panakkal NC, Dkhar W, Pradhan A, Chandrasekaran B, Palaniswamy HP, Paramashiva PS, Ravichandran S, Muthu SS, Kamath K.   +12 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Der Blick zurück in die jüngste Vergangenheit. Die Bewährungshilfe im Kanton Bern im ausgehenden 20. und frühen 21. Jahrhundert - ein Gespräch mit Michael Imhof, Marianne Isenschmid und Hanspeter Michel

, 2011
Matter, Sonja
core  

White matter microstructural alterations in episodic cluster headache outside attacks: a tract-based spatial statistics study. [PDF]

J Headache Pain
Caramia F, Di Renzo A, Giuliani G, Chiffi D, Di Lorenzo C, Colangelo A, De Maio A, Della Volpe L, Fiorelli M, Di Stefano G, Altieri M, Coppola G.   +11 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Front Matter Vol. 8 No. 1, 2024

Front Matter Vol. 8 No.
Front Matter
core  

The impact of fertilization on the health of paddy soil: pathways and prospects for fertility regulation based on microbial communities. [PDF]

Crop Health
Xu H, Shu A, Gan S, Han X, Zhang X, Zhang W, Liu Z, Ma J, Shi W, Gao Z.   +9 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Glymphatic System Visualized With Intrathecal Gadoterate Meglumine Administered via External Ventricular Drain. [PDF]

Cureus
Wong C, Siddiqi I, Reier L, Wang A, Marino M, Tchalukov K, Nguyen C, Miulli DE.   +7 more
europepmc   +1 more source