Results 151 to 160 of about 1,626,816 (264)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Hydrocarbon Generation Potential, Paleoenvironmental Conditions, and Organic Matter Enrichment of the Fengcheng Formation Black Shales in the Hala'alat Mountain, NW Junggar Basin: Chemostratigraphic Insights from Well HQ‑6. [PDF]

ACS Omega
Li Z, Zhang S, Zhou J, Song M, Bai J, Zhang L, Jia Y, Liu R, Guo H, Hu'anishen J, Wei Y.   +10 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Feed binders to improve the quality of Atlantic salmon (<i>Salmo salar</i>) feed and faeces. [PDF]

PeerJ
Bogevik AS, Samuelsen TA, Meriac A, Alvestad R, Aas TS.   +4 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Composite grey matter fingerprints for genetic frontotemporal dementia. [PDF]

J Neurol Neurosurg Psychiatry
Bouzigues A, Campana G, Joulot M, Gensollen N, Russell LL, Foster PH, Ferry-Bolder E, Van Swieten JC, Jiskoot LC, Seelaar H, Sánchez-Valle R, Laforce R, Graff C, Galimberti D, Vandenberghe R, de Mendonca A, Tiraboschi P, Santana I, Gerhard A, Levin J, Sorbi S, Otto M, Bertoux M, Lebouvier T, Ducharme S, Butler C, Finger E, Tartaglia MC, Masellis M, Rowe JB, Synofzik M, Moreno F, Borroni B, Leber I, Zanusso G, Rohrer JD, Migliaccio R, GENetic Frontotemporal dementia Initiative (GENFI).   +37 more
europepmc   +1 more source

The Things That Matter

Design Issues, 1998
Verbeek, Peter P.C.C., Kockelkoren, P.J.H.   +1 more
openaire   +3 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Structural Brain Pathways Linking White Matter Hyperintensities to Pain Sensitivity

Liu X, Vangberg TR, Kuiper LM, Vernooij MW, Stubhaug A, Steingrímsdóttir ÓA, Page CM, Nielsen CS, van Meurs JBJ, Roshchupkin GV.   +9 more
europepmc   +1 more source

High-fat diet is associated with accelerated gray matter atrophy in cognitively unimpaired older adults but slower atrophy in individuals with existing mild cognitive impairment. [PDF]

Alzheimers Dement
Fan L, Sun Y, Liu D, Robb WH, Pechman KR, Shashikumar N, Vyas Y, Landman BA, Hohman TJ, Jefferson AL.   +9 more
europepmc   +1 more source