Results 181 to 190 of about 1,545,669 (264)

Adiponectin Fortifies White Matter After Chronic Hypoperfusion-Induced Vascular Dementia. [PDF]

Stroke
Miao W, Xu F, Pu H, Shan J, Lyu J, Mai TW, Tian Q, Pandya A, Barreiro J, Jiang L, Wang H, Stetler RA, Leak RK, Chen J, Hu X.   +14 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Synthesis of Amyloid Images Using a Generative Adversarial Network from 2-Dimensional ¹⁸F-FDG Images and Evaluation for Clinical Use. [PDF]

J Nucl Med Technol
Honda M, Yamada T, Watanabe S, Watanabe A, Nagaoka T, Nemoto M, Mikami K, Hanaoka K, Kaida H, Handa H, Ishii K, Kimura Y.   +11 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Association of Weight-Adjusted-Waist Index With Brain Health: A 16-Year Population-Based Longitudinal Cohort Study. [PDF]

CNS Neurosci Ther
Sun Q, Yu L, Yang L, Liang Y, Qi Q, Hui Y, Xu M, Wang Z, Wu S, Wu Y, Lv H.   +10 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Impact of physical activity and exercise interventions on white matter integrity in overweight and obese populations: A systematic review and meta-analysis. [PDF]

Compr Psychoneuroendocrinol
Shettigar D, Sukumar S, Kadavigere R, Vaishali K, Panakkal NC, Dkhar W, Pradhan A, Chandrasekaran B, Palaniswamy HP, Paramashiva PS, Ravichandran S, Muthu SS, Kamath K.   +12 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Glymphatic System Visualized With Intrathecal Gadoterate Meglumine Administered via External Ventricular Drain. [PDF]

Cureus
Wong C, Siddiqi I, Reier L, Wang A, Marino M, Tchalukov K, Nguyen C, Miulli DE.   +7 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source