Results 191 to 200 of about 1,548,999 (264)

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Methane mitigation, nutritional evaluation, and in vitro degradation kinetics of diets based on tropical grass haylage treated with xylanase. [PDF]

Trop Anim Health Prod
Duarte ABA, Dias-Silva TP, Viana WCC, Gurgel ALC, Araújo MJ, Abdalla AL, Bezerra LR, Edvan RL, Nascimento RR, Sousa SV, Marques CAT, Ítavo LCV, Lima PMT.   +12 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Glymphatic System Visualized With Intrathecal Gadoterate Meglumine Administered via External Ventricular Drain. [PDF]

Cureus
Wong C, Siddiqi I, Reier L, Wang A, Marino M, Tchalukov K, Nguyen C, Miulli DE.   +7 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Synthesis of Amyloid Images Using a Generative Adversarial Network from 2-Dimensional ¹⁸F-FDG Images and Evaluation for Clinical Use. [PDF]

J Nucl Med Technol
Honda M, Yamada T, Watanabe S, Watanabe A, Nagaoka T, Nemoto M, Mikami K, Hanaoka K, Kaida H, Handa H, Ishii K, Kimura Y.   +11 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Impact of physical activity and exercise interventions on white matter integrity in overweight and obese populations: A systematic review and meta-analysis. [PDF]

Compr Psychoneuroendocrinol
Shettigar D, Sukumar S, Kadavigere R, Vaishali K, Panakkal NC, Dkhar W, Pradhan A, Chandrasekaran B, Palaniswamy HP, Paramashiva PS, Ravichandran S, Muthu SS, Kamath K.   +12 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Association of Weight-Adjusted-Waist Index With Brain Health: A 16-Year Population-Based Longitudinal Cohort Study. [PDF]

CNS Neurosci Ther
Sun Q, Yu L, Yang L, Liang Y, Qi Q, Hui Y, Xu M, Wang Z, Wu S, Wu Y, Lv H.   +10 more
europepmc   +1 more source