Results 121 to 130 of about 1,981,828 (283)
Advanced Science, EarlyView.Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao +16 more
wiley +1 more source
The Uses of Adversity: Matthew Flinders' Mauritius Writings [PDF]
, 2002 A discussion of Matthew Flinders' 'Biographical Tribute to the Memory of Trim' and of an extended journal entry, both written while he was detained on ...
Dooley, Gillian Mary
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Advanced Science, EarlyView.When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley +1 more source
Book review: the Labour party and the world: Labour’s foreign policy since 1951 [PDF]
, 2012 Rhiannon Vickers should be congratulated for delivering a concise, balanced, and accessible account of how left of centre thinking on foreign policy has evolved over the last sixty years, writes Matthew ...
Partridge, Matthew
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Advanced Science, EarlyView.The formation of insulating Li2S during discharge in solid‐state lithium–sulfur batteries passivate reaction sites and limits sulfur utilization. In this work, a microstructure‐resolved modeling framework coupling transport and reaction kinetics is developed to predict charge–discharge behavior and reveal particle‐scale species evolution and incomplete
Arpan K. Sharma +4 more
wiley +1 more source
Purple rinses and pseudo escofferian menus : the problem with training restaurants [PDF]
, 2007 Just as training restaurants seemed to be on their way out for good, Matthew Alexander reports that they are enjoying a new lease of life as a much-needed contributor to institutional income, with a new commercial edge and in one case a research ...
Alexander, Matthew
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Advanced Science, EarlyView.Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen +9 more
wiley +1 more source
Unveiling a Bulk WTaV Multicomponent Alloy With Superior Thermal Properties and Manufacturability
Advanced Science, EarlyView.ABSTRACT Many tungsten (W)‐based medium and high entropy alloys (HEA) demonstrate superior microstructural stability and enhanced mechanical properties as compared to pure W, effectively rendering them as viable candidate materials for extreme environments such as nuclear fusion, aerospace applications, and so on.
Ishtiaque K. Robin +11 more
wiley +1 more source
Book review: the struggle for Egypt: from Nasser to Tahrir Square [PDF]
, 2011 Steven Cook’s master-class in Egyptian political history since the military coup in 1952 is essential to understanding the political tensions between militarists, Islamists, and democrats which persist up to the present day, finds Matthew ...
Partridge, Matthew
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