Results 41 to 50 of about 2,688,672 (311)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

Life course explanations of consumer responses to threats: the case of COVID-19

open access: yesCogent Business & Management, 2022
Marketing managers and researchers have had a long-standing interest in understanding the onset of new patterns of consumer behavior, but they have had few theoretical and methodological tools for studying the onset and stability of consumption patterns ...
Sarinya L. Suttharattanagul   +2 more
doaj   +1 more source

A novel element upstream of the Vgamma2 gene in the murine T cell receptor gamma locus cooperates with the 3 enhancer to act as a locus control region. [PDF]

open access: yes, 1999
Transgenic expression constructs were employed to identify a cis-acting transcription element in the T cell receptor (TCR)-gamma locus, called HsA, between the Vgamma5 and Vgamma2 genes. In constructs lacking the previously defined enhancer (3E(Cgamma1)),
Baker, J   +5 more
core  

ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints. A novel pathogenic mechanism in chronic arthritis [PDF]

open access: yes, 2017
To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis ...
Benedetti, Fabrizio De   +9 more
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke   +4 more
wiley   +1 more source

Advances and outlook of integrated reservoir-wellbore-pipe network simulation technology

open access: yesEnergy Geoscience
The integrated simulation and optimization technology of reservoir-wellbore-pipe network is developed to reflect the mutual influence and restriction among reservoir engineering, oil production engineering and surface engineering, and to obtain the ...
Hongmin Yu   +5 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Animating erotica without shame: an autoethnographic creative account

open access: yesCreativity Studies
This article explores the experience of shame and guilt that is associated with producing explicit erotic animated content. By employing the reflective practice journaling method, this autoethnographic essay discusses cultural and psychological ...
Tomas Mitkus
doaj   +1 more source

Mature cystic teratoma of renal pelvis: An unusual presentation at an uncommon site

open access: yesJournal of Indian Association of Pediatric Surgeons, 2019
Teratoma of the kidney is uncommon. We report a case of a young boy with a large, right-sided retroperitoneal cyst suspected as lymphangioma causing hydronephrosis. His renal pelvis was dilated, containing purulent fluid, and a nephrectomy was performed.
Bhuvanagiri Srihari Balaji   +1 more
doaj   +1 more source

How to make a mature accreting magnetar [PDF]

open access: yes, 2017
Several candidates for accreting magnetars have been proposed recently by different authors. Existence of such systems contradicts the standard magnetic field decay scenario where a large magnetic field of a neutron star reaches $\lesssim$ few$\times 10^{
Igoshev, A. P., Popov, S. B.
core   +3 more sources

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