Results 91 to 100 of about 356,409 (302)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Quantitative Classification and Prediction of Starkrimson Pear Maturity by Near-Infrared Spectroscopy

Foods
Scientific evaluation of pear maturity is important for commercial reasons. Near-infrared spectroscopy is a non-destructive method that could be used for rapid assessment of pear maturity.
Ruitao Lu, Linqian Qiu, Shijia Dong, Qiyang Xue, Zhaohui Lu, Rui Zhai, Zhigang Wang, Chengquan Yang, Lingfei Xu   +8 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

DOES THE SPOT CURVE CONTAIN INFORMATION ON FUTURE MONETARY POLICY IN COLOMBIA? [PDF]

In order to asses the credibility of their targets and policies, inflation targeting central banks always keep an eye on market expectations of the future inflation rates and short maturity interest rates.
Juan Manuel Julio Román
core  

Reproductive biology of blue marlin (Makaira nigricans) in the western Pacific Ocean [PDF]

, 2009
The reproductive biology of blue marlin (Makaira nigricans) was assessed from 1001 fish (ranging from 121 to 275 cm in eye-to-fork length; EFL) caught by Taiwanese offshore longliners in the western Pacific Ocean from September 2000 to December ...
Chien-Chung Tszeng, Chien-Chung Tszeng, Su-Zan Yeh, Su-Zan Yeh, Sun, Chi-Lu, Yi-Jay Chang, Yi-Jay Chang   +3 more
core  

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Results from the Crop Identification Technology Assessment for Remote Sensing (CITARS) project [PDF]

The author has identified the following significant results. It was found that several factors had a significant effect on crop identification performance: (1) crop maturity and site characteristics, (2) which of several different single date automatic ...
Bauer, M. E., Bizzell, R. M., Davis, B. J., Feiveson, A. H., Hall, F. G., Malila, W. A., Rice, D. P.   +6 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Acoustic response discrimination of phulae pineapple maturity and defects using factor analysis of mixed data and machine learning algorithms

Smart Agricultural Technology
Acoustic response is non-destructive evaluation technique that replicates the conventional method for determining maturity by tapping the fruit. The physical (dimensions, color, firmness, and specific gravity) chemical (TSS, %TA, and TSS/TA), and ...
Sujitra Arwatchananukul, Saowapa Chaiwong, Nattapol Aunsri, Sila Kittiwachana, Kietsuda Luengwilai, Tatiya Trongsatitkul, Pramod Mahajan, Jose Blasco, Rattapon Saengrayap   +8 more
doaj   +1 more source