Results 151 to 160 of about 65,498 (306)

Camrelizumab plus albumin-bound paclitaxel and S-1 as first-line treatment for patients with human epidermal growth factor receptor 2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial. [PDF]

Front Immunol
Wu C, Li S, Hou X.
europepmc   +1 more source

Adverse Selection and Financial Crises [PDF]

The recent financial crisis has highlighted the importance of adverse selection as a contributing factor to financial market instability. In this article, the author examines the phenomenon of adverse selection and explains how its presence in a ...
Koralai Kirabaeva
core  

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Cooling artifacts in ex-situ pore characterization of thermally stimulated low-maturity shale: an in-situ SEM imaging reassessment. [PDF]

Sci Rep
Cheng L, Xu X, Gou J, Liu C, Han K, Jiang C, Liu N, Meng C, Liu J.   +8 more
europepmc   +1 more source

Does short-term debt increase vulnerability to crisis? Evidence from the East Asian financial crisis [PDF]

Does short-term debt increase vulnerability to financial crisis, or does causality go the other way, so that short term debt reflects rather than causes the incipient crisis?
Efraim Benmelech, Eyal Dvir
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Impact of stromal maturity and proportion on prognosis and immune landscape in colorectal cancer. [PDF]

Ann Med
Tapiainen VV, Sirniö P, Karjalainen H, Äijälä VK, Kastinen M, Pohjanen VM, Elomaa H, Sirkiä O, Ahtiainen M, Helminen O, Wirta EV, Lindgren O, Mattila TT, Rintala J, Meriläinen S, Saarnio J, Rautio T, Seppälä TT, Böhm J, Mecklin JP, Tuomisto A, Mäkinen MJ, Väyrynen JP.   +22 more
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

SCEA-YOLO: A General-Purpose Maturity Grading Model of Multi-Crop Greenhouse Robots. [PDF]

Plants (Basel)
Li T, Liu P, Song D, Zhao X, Lyu X, Zhang K.   +5 more
europepmc   +1 more source

Distributions Implied by Exchange Traded Options: A Ghost’s Smile? [PDF]

A new and easily applicable method for estimating risk neutral distributions (RND) implied by American futures options is proposed. It amounts to inverting the Barone-Adesi and Whaley method (1987) (BAW method) to get the BAW-implied volatility smile ...
Martin Cincibuch
core