Results 121 to 130 of about 136,721 (312)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Operationalizing a learning health system: A self‐assessment tool for interprofessional teams

Learning Health Systems
Background The operationalization of learning health system (LHS) principles remains challenging, with minimal guidance currently available to support interprofessional teams on the ground. Consequently, LHS initiatives often fall short of their intended
Victor C. Rentes, Claire Kalpakjian, Anne Sales, Andrew Krumm   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

[The maturity model for the public health service-a tool for assessing and improving the digital maturity level of German public health agencies]. [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2023
Eymann T, Fürstenau D, Gersch M, Kauffmann AL, Neubauer M, Schick D, Schlömer N, Schulte-Althoff M, Stark J, von Welczeck L.   +9 more
europepmc   +1 more source

On the Modeling of Debt Maturity and Endogenous Default: A Caveat

, 2008
Jean‐Paul Décamps, Stéphane Villeneuve   +1 more
openalex   +1 more source

CERT-UA assessment based on the CSIRT ENISA Maturity Model

, 2023
Oleksandr Peliukh, M.V. Yesina, D.Yu. Holubnychyi   +2 more
openalex   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

A JOINT MATURITY MODEL OF BI-DRIVEN SUPPLY CHAINS [PDF]

, 2014
Iris Hausladen, Alexander Haas
openalex  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

EVALUATION OF DIGITAL TRANSFORMATION MATURITY MEASUREMENT MODELS

, 2022
Mehmet Ekim AYYILDIZ, Ahmet Oğuz Demir
openalex   +1 more source