Results 51 to 60 of about 136,797 (255)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Testing the key processes that accelerate outer radiation belt relativistic electrons during geomagnetic storms

Frontiers in Astronomy and Space Sciences, 2023
Since the discovery of the Earth’s radiation belts in 1958, it has always been a challenge to determine the dominant physical mechanisms, whether local acceleration by chorus or inward radial diffusion, that leads to outer radiation belt relativistic ...
Man Hua, Jacob Bortnik, Harlan E. Spence, Geoffrey D. Reeves, Geoffrey D. Reeves   +4 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Spatial risk measures for max-stable and max-mixture processes [PDF]

Stochastics, 2019
In this paper, we consider isotropic and stationary max-stable, inverse max-stable and max-mixture processes $X=(X(s))\_{s\in\bR^2}$ and the damage function $\cD\_X^ν= |X|^ν$ with ...
Ahmed, Manaf, Maume-Deschamps, Véronique, Ribereau, Pierre, Vial, Céline   +3 more
openaire   +4 more sources

Ocean biogeochemistry in the warm climate of the late Paleocene [PDF]

Climate of the Past, 2015
The late Paleocene is characterized by warm and stable climatic conditions that served as the background climate for the Paleocene–Eocene Thermal Maximum (PETM, ~55 million years ago).
M. Heinze, T. Ilyina
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Coexistence of reward and unsupervised learning during the operant conditioning of neural firing rates.

PLoS ONE, 2014
A fundamental goal of neuroscience is to understand how cognitive processes, such as operant conditioning, are performed by the brain. Typical and well studied examples of operant conditioning, in which the firing rates of individual cortical neurons in ...
Robert R Kerr, David B Grayden, Doreen A Thomas, Matthieu Gilson, Anthony N Burkitt   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Method of constructing logical-event computational models of transforming social information processes

Вестник Самарского университета: Естественнонаучная серия
The article develops a method for organizing a logical-event hybrid model for analyzing socioinformational processes in their stages, event transformations and rapid disturbances.
A. Yu. Perevaryukha
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source