Results 61 to 70 of about 495,992 (279)

Verdad y política: la crítica de Eric Voegelin a Max Weber sobre la relación entre ciencia y valores. [PDF]

, 2006
Aquest article es proposa analitzar la crítica d’Eric Voegelin a Max Weber sobre la relació entre ciència i valors, per tal de veure les seves implicacions en la història del concepte de política a Occident.
Franzé, Javier
core  

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Le projet dans les recompositions des politiques de santé mentale

Lien Social et Politiques, 2012
Les politiques psychiatriques et les politiques sociales se rejoignent aujourd’hui autour d’un principe qui consiste à mettre la personne et son projet de vie au centre des interventions dans une perspective de « rétablissement ».
Benoît Eyraud, Pierre A. Vidal-Naquet
doaj   +1 more source

Legal Scholarship as a Vocation [PDF]

, 2001
Law professors occupy a twin role as scholars and (most of them, at any rate) as lawyers. Deborah Rhode has pointed out, in her contribution to this symposium, that the lawyer role of the professor carries with it some frequently overlooked obligations ...
Luban, David
core   +1 more source

Reflexiones metodológicas en torno a la comprensión de la acción social : contribuciones, discusiones y tensiones entre algunas perspectivas comprensivistas, fenomenológicas y hermenéuticas [PDF]

, 2011
¿Qué es la acción social? ¿cómo definimos qué es la acción? ¿cómo comprendemos una acción social? ¿qué es comprender?, ¿qué es explicar?, etc., son algunas de las preguntas que guían el presente texto. En él, buscamos ensayar algunas reflexiones en torno
Alejandra Parra, Marcela
core   +4 more sources

FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

Advanced Science, EarlyView.
Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He   +15 more
wiley   +1 more source

Max Weber on Politics, Reason, and the Clash of Values and Approaches to Ethics [PDF]

, 2019
This article investigates how Max Weber’s theory of value conflict is connected to his realist understanding of politics and how he conceives the relation of politics and ethics. This investigation also covers Weber’s views on the argumentative limits of
Dr Knoll, Manuel
core   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

The Weber-chord: an analysis of Max Weber theory identity through a musical metaphor
O Acorde-Weber: uma análise sobre a identidade teórica de Max Weber

Semina: Ciências Sociais e Humanas, 2010
This article aims to develop some considerations about the relations between Objectivity and Subjectivity in the Sociology of Max Weber and in his historiographic thought.
José D’Assunção Barros
doaj  

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source