Results 31 to 40 of about 365,043 (252)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

THE HISTORY AND PRESENT SITUATION OF MONGOLIAN ORAL & MAXILLOFACIAL SURGERY [PDF]

, 2000
Mongolia is a huge, landlocked, middle-Asian country bordering Russia in the north, and China in the south. Mongolia was under socialism from 1921 to 1990, and its political system has started moving toward capitalistic democratism in 1990.
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core  

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Insular volume abnormalities associated with different transition probabilities to psychosis [PDF]

, 2011
Background Although individuals vulnerable to psychosis show brain volumetric abnormalities, structural alterations underlying different probabilities for later transition are unknown.
McGuire, P., A. Riecher-Rössler, Simon, A., Simon, A, P. Fusar-Poli, Lenz, C., Fusar-Poli P., Riecher-Rössler, A., Bendfeldt, K, Stieglitz, R D, Riecher-Rössler, A, S. J. Borgwardt, McGuire, P, Borgwardt, S. J., J. Aston, Smieskova R., Bendfeldt K., Lenz C., Smieskova, R., Borgwardt, S J, Riecher-Rossler A., R. Smieskova, Riecher-Roessler, A., P. McGuire, Fusar-Poli, P, Simon A., A. Simon, Borgwardt S. J., K. Bendfeldt, Aston, J, Bendfeldt, K., Stieglitz, R. -D., Lenz, C, Stieglitz R. -D., Stieglitz, R.-D., R.-D. Stieglitz, Fusar-Poli, P., Aston J., McGuire P., Fusar-Poli, P.; id_orcid, Smieskova, R, C. Lenz, Aston, J.   +42 more
core   +2 more sources

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Sport-related maxillofacial fractures

, 2016
Sports and exercise are important causes of maxillofacial injuries. Different types of sports might differ in frequency and type of fractures. The aim of the present study was to explore the possible relation between the types of sport practiced and the ...
ten Brincke, Y. J. D., Brand, H.S.; id_orcid, Ruslin, M., Ruslin, Muhammad, ten Brincke, Y.J.D., Forouzanfar, T., Boffano, P., Brand, Henk S., Forouzanfar, Tymour, Boffano, Paolo, Brand, H.S.   +10 more
core   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

New PCNT candidate missense variant in a patient with oral and maxillofacial osteodysplasia: a case report

BMC Medical Genetics, 2019
Background Osteodysplasia of the oral and maxillofacial bone is generally accompanied by systemic bone abnormalities (such as short stature, joint contracture) or other systemic abnormalities (such as renal, dermatological, cardiovascular, optic, or ...
Ken-ichi Aoyama, Minoru Kimura, Hiroshi Yamazaki, Masahiro Uchibori, Rena Kojima, Yuko Osawa, Kazuyoshi Hosomichi, Yoshihide Ota, Masayuki Tanaka, Shiro Yamada, Gen Nishimura   +10 more
doaj   +1 more source

Dual‐Targeted Biomimetic MoSe2 Nanozymes for Enhancing Peri‐Implant Soft Tissue Integration

Advanced Science, EarlyView.
A dual‐targeting biomimetic nanozyme, MoSe2@SPMM, selectively targets Staphylococcus aureus and oxidatively stressed macrophages. Near‐infrared activation couples contact‐enhanced photothermal bacterial eradication with reactive oxygen species scavenging to disrupt the pathogenic–immunological amplification loop.
Minghao Zhou, Miaomiao Tian, Jingwei Yu, Jiaxin Kang, Miaomiao Chen, Yue Yuan, Lizhi Liu, Hongbo Wei   +7 more
wiley   +1 more source

Fabrication of localizing template for extraoral implant in a patient with congenital defect in one ear

Dental Hypotheses, 2014
Introduction: The use of osseointegrated extraoral implants for retention of extraoral prostheses, such as ears offers ideal support and retention, and improves patient′s appearance and quality of life.
Susan Mir Mohammad Rezaei, Fatemeh Nematollahi   +1 more
doaj   +1 more source