Results 91 to 100 of about 177,624 (292)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

CAS MAXIMA AS A TOOL FOR FORMING RESEARCH SKILLS IN THE PROCESS OF PRE-SERVICE INFORMATICS TEACHERS TRAINING

, 2020
Тарас Кобильник, Уляна Петрівна Когут, Наталія Винницька   +2 more
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

P437: EFFECTIVE IMMUNOTHERAPY OF PEDIATRIC T(8;21) ACUTE MYELOID LEUKEMIA BY REPURPOSING CD3XCD19 TARGETING BISPECIFIC ANTIBODIES

HemaSphere, 2023
Noa Wijnen, Farnaz Barneh, Thomas Meulendijks, Kim Klein, Ester Duddebach, Annelisa Cornel, Noël Dautzenberg, Minoo Ashtiani, Anja Krippner-Heidenreich, Stefan Nierkens, Olaf Heidenreich, Gertjan Kaspers   +11 more
doaj   +1 more source

Phantom design for tracked ultrasound-based surgical navigation systems

MethodsX
For pediatric oncology patients, radical tumor removal is crucial. Surgical navigation using tracked ultrasound may improve radical removal rates in pediatric surgery, based on positive clinical outcomes in adult tumor surgery.
V.J. van Boheemen, J.M. van der Zee, M. Kuipers, M. Fitski, M.H.W.A. Wijnen, F.J. Siepel, A.F.W. van der Steeg   +6 more
doaj   +1 more source

Development of Nutritious Biscuit by Substitution of Wheat Flour using Composite Flour of Pumpkin (<em>Cucurbita maxima</em>), Corn (Zea mays) and Soybean (<em>Glycine max</em>) and Quality Evaluation [PDF]

, 2023
W. M. D. S. N. Wanigasooriya, P. C. Arampath, Chandi Kanchana Deepali Wellala   +2 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Clinical presentation and outcome of invasive mould disease in paediatric patients with acute lymphoblastic leukaemia

EJC Paediatric Oncology
Background: Childhood acute lymphoblastic leukaemia (ALL) cure rates have improved, but invasive mould disease (IMD) remains a life-threatening complication.
Didi Bury, Corline E.J. Parmentier, Wim J.E. Tissing, Rob Pieters, Louis J. Bont, Roger J. Brüggemann, Tom F.W. Wolfs   +6 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

¿Es Alstroemeria pulchra Sims var. maxima Phil. (Alstroemeriaceae) un miembro del complejo A. magnifica Herbert?: Estudio colorimétrico de los tépalos externos e internos de la flor [PDF]

, 2015
Víctor L. Finot, Carlos M. Baeza, Pedro Melín, Patricio Novoa, Jorge Campos, Eduardo Ruíz, Glenda Fuentes, Paula Daniela Albornoz, Pedro Carrasco   +8 more
openalex   +1 more source