Results 11 to 20 of about 177,624 (292)

Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch

Journal for ImmunoTherapy of Cancer, 2022
Background Immunotherapy in high-risk neuroblastoma (HR-NBL) does not live up to its full potential due to inadequate (adaptive) immune engagement caused by the extensive immunomodulatory capacity of HR-NBL.
Judith Wienke, S Nierkens, Miranda P Dierselhuis, Jan J Molenaar, Annelisa M Cornel, Ester Dunnebach, Damon A Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Josephine G M Strijker, Denise A M H van den Beemt, Anke H W Essing, Bianca Koopmans, Sem A G Engels, Vania Lo Presti, Celina S Szanto, Rani E George, Sebastiaan van Heesch   +18 more
doaj   +1 more source

New Patterns in Steady-State Chemical Kinetics: Intersections, Coincidences, Map of Events (Two-Step Mechanism)

Entropy, 2015
New patterns of steady-state chemical kinetics for continuously stirred-tank reactors (CSTR) have been found, i.e., intersections, maxima and coincidences, for two-step mechanism A↔B→C.
Daniel Branco Pinto, Gregory Yablonsky, Guy B. Marin, Denis Constales   +3 more
doaj   +1 more source

Morphological evidence by scanning electron microscopy of excretion of metacyclic forms of Trypanosoma cruzi in vector's urine

Memorias do Instituto Oswaldo Cruz, 1988
Comparision by scanning electron microscopy (SEM) of Trypanosoma cruzi flagellates attached to the cuticle of the rectal gland of infected Dipetalogaster maxima nymphs, showed marked differences before amd after feeding.
Rodrigo Zeledon, Rodolfo Bolaños, M. R. Espejo Navarro, Miguel Rojas   +3 more
doaj   +1 more source

Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte transdifferentiation through cooperative BAP1 and PRKAR2A loss

Nature Communications, 2023
Fibrolamellar carcinoma (FLC) is a lethal primary liver cancer, affecting young patients in absence of chronic liver disease. Molecular understanding of FLC tumorigenesis is limited, partly due to the scarcity of experimental models.
Laura Rüland, Francesco Andreatta, Simone Massalini, Susana Chuva de Sousa Lopes, Hans Clevers, Delilah Hendriks, Benedetta Artegiani   +6 more
doaj   +1 more source

Fluorescence guided surgery using indocyanine green for pulmonary osteosarcoma metastasectomy in pediatric patients: A feasibility study

EJC Paediatric Oncology, 2023
Background: In osteosarcoma patients, resection of pulmonary metastases is considered necessary for long term survival. Radiologically detected lesions are sometimes difficult to identify intraoperatively, especially when no palpation is possible during ...
Bernadette Jeremiasse, Caroline C.C. Hulsker, Ceder H. van den Bosch, Myrthe A.D. Buser, Cornelis P. van der Ven, Guus M.J. Bökkerink, Marc H.W.A. Wijnen, Alida F.W. Van der Steeg   +7 more
doaj   +1 more source

Axonal Injury with Persistent Neuropathy following Popliteal Nerve Block for Cheilectomy Surgery

Case Reports in Anesthesiology, 2021
Peripheral nerve blocks are often used for foot and ankle surgery. The occurrence of persistent neurological symptoms thereafter is very rare. Preventive strategies pose no guarantee and uncovering true etiology is often complicated. We discuss a case in
Y. A. M. Kuijpers, J. M. Setz, K. Khemlani-Houthoff   +2 more
doaj   +1 more source

Oxygenator Evaluation: Maxima 1380 Versus Maxima Plus

The Journal of ExtraCorporeal Technology, 1995
Continual improvement of oxygenators has been important in the growing demands of patient safety and support during cardiopulmonary bypass. The purpose of this study was to compare the Maxima 1380 oxygenator to the upgraded Maxima Plus oxygenator. Thirty-two adult patients were randomized to either the 1380 group or the Plus group.
J H, Engle, J, Ploessl, R, Sutton
openaire   +2 more sources

Some new retarded nonlinear Volterra-Fredholm type integral inequalities with maxima in two variables and their applications

Journal of Inequalities and Applications, 2017
In this paper, we establish some new retarded nonlinear Volterra-Fredholm type integral inequalities with maxima in two independent variables, and we present the applications to research the boundedness of solutions to retarded nonlinear Volterra ...
Run Xu, Xiangting Ma
doaj   +1 more source

Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways

Frontiers in Oncology, 2022
Although long-term survival in pediatric acute lymphoblastic leukemia (ALL) currently exceeds 90%, some subgroups, defined by specific genomic aberrations, respond poorly to treatment.
Miriam Butler, Miriam Butler, Britt M.T. Vervoort, Dorette S. van Ingen Schenau, Lieneke Jongeneel, Jordy C.G. van der Zwet, René Marke, Jules P.P. Meijerink, Blanca Scheijen, Blanca Scheijen, Laurens T. van der Meer, Frank N. van Leeuwen   +11 more
doaj   +1 more source

PhaPl: software to plot and research phase portraits automatically

Открытое образование (Москва), 2017
The article aims to document PhaPl that’s a teaching software to plot and research phase portraits of autonomous systems of 2 differential equations on a plane. Interactive computer teaching materials allow to demonstrate tasks describing large number of
A. A. Cherepanov
doaj   +1 more source