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Multivariate maxima of moving multivariate maxima [PDF]

open access: yesStatistics & Probability Letters, 2012
We define a class of multivariate maxima of moving multivariate maxima, generalising the M4 processes. For these stationary multivariate time series we characterise the joint distribution of extremes and compute the multivariate extremal index. We derive the bivariate upper tail dependence coefficients and the extremal coefficient of the new limiting ...
openaire   +3 more sources

Comparing the efficacy of targeted spinal cord stimulation (SCS) of the dorsal root ganglion with conventional medical management (CMM) in patients with chronic post-surgical inguinal pain: the SMASHING trial

open access: yesBMC Surgery, 2018
Background A significant number of patients who undergo a standard inguinal hernia repair or a Pfannenstiel incision develop chronic (> 3 months) post-surgical inguinal pain (PSIP) due to nerve entrapment.
Frederique M. U. Mol   +2 more
doaj   +1 more source

The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML

open access: yesHemaSphere, 2023
Chromosomal translocations involving the NUP98 locus are among the most prevalent rearrangements in pediatric acute myeloid leukemia (AML). AML with NUP98 fusions is characterized by high expression of HOXA and MEIS1 genes and is associated with poor ...
Milad Rasouli   +10 more
doaj   +1 more source

CATERPILLAR-study protocol: an assessor-blinded randomised controlled trial comparing taurolidine-citrate-heparin to heparin-only lock solutions for the prevention of central line-associated bloodstream infections in paediatric oncology patients

open access: yesBMJ Open, 2023
Introduction The efficacy of taurolidine containing lock solutions for the prevention of central line-associated bloodstream infections (CLABSI) in paediatric oncology patients is still unknown. If the taurolidine-citrate-heparin lock appears to decrease
Marta Fiocco   +8 more
doaj   +1 more source

A systematic review of health-related quality of life in children and adolescents during treatment for cancer

open access: yesEJC Paediatric Oncology, 2023
Health-related quality of life (HRQL) is a multidimensional concept which captures the individual’s perception of treatment burden. Evaluating HRQL during treatment for childhood cancer provides insight into the burden of the treatment from the child’s ...
Anne Bakker   +6 more
doaj   +1 more source

Parental experiences of children with developmental dysplasia of the hip: a qualitative study

open access: yesBMJ Open, 2022
Objective The aim of this qualitative study was to explore the experiences of Dutch parents of children with developmental dysplasia of the hip (DDH), treated with a Pavlik harness, during the diagnostic and treatment process in the first year of life ...
WWES Theunissen   +5 more
doaj   +1 more source

Primary angle-closure glaucoma, a rare but severe complication after blepharoplasty: Case report and review of the literature

open access: yesArchives of Plastic Surgery, 2018
Blepharoplasty is one of the most commonly performed aesthetic procedures. Surgical complications are rare, but can have severe consequences, such as permanent vision loss.
Isabelle Francisca Petronella Maria Kappen   +3 more
doaj   +1 more source

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

open access: yesHaematologica, 2020
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity in initial diagnosis, with multiple (sub)clones harboring lesions in relapse-associated genes.
Željko Antić   +13 more
doaj   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale   +6 more
wiley   +1 more source

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