Results 61 to 70 of about 27,496 (207)
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
La recherche du « bon » principe d’économie en physique
Etudes EpistémèThe search for the “right” principle of economy is a central epistemological question. In fact, the debate over the path taken by refracted light (is it the shortest or the quickest?) epitomizes the controversy over the role of metaphysics in physics ...
Véronique Le Ru
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Hydrolysis of Acetic Anhydride in a CSTR
Undergraduate Journal of Mathematical Modeling: One + Two, 2016 To find the optimal reactor volume and temperature for the hydrolysis of acetic anhydride at the lowest possible cost with a 90% conversion of acetic anhydride, a formula for the total cost of the reaction was created.
Veronica N. Coraci
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Thickness Dependent Dielectric Loss of Plasma Poly (Ethylene Oxide) Films
Cumhuriyet Science Journal, 2018 Dielectric properties of plasma poly (ethyleneoxide) (pPEO) thin film samples were investigated at room temperature. The thinfilm samples with different thicknesses were deposited by plasma assistedphysical vapor deposition (PAPVD) technique at 5 W ...
Hulusi Kemal Ulutaş
doaj +1 more source