Summary Introduction Facemask ventilation is a key airway management skill but predicting difficulty can be challenging. Pre‐operative three‐dimensional face scanning may have diagnostic value. We aimed to identify interpretable facial shape features and to quantify their value for predicting difficult facemask ventilation.
Viktor A. Wünsch +9 more
wiley +1 more source
Concavity of the maximal expiratory flow-volume curve, and incidence of COPD and respiratory symptoms: a population-based cohort study. [PDF]
Tan DJ +11 more
europepmc +1 more source
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon +3 more
wiley +1 more source
Positive end-expiratory pressure in pediatric acute respiratory distress syndrome: a narrative review. [PDF]
Allen L +4 more
europepmc +1 more source
Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Paulette Magnas +16 more
wiley +1 more source
Dynamic hyperinflation occurs in healthy subjects during maximal voluntary ventilation. [PDF]
Herpeux A +5 more
europepmc +1 more source
CCR2/CCR5 Signaling Defines a Pathogenic Interstitial Macrophage Subset That Drives Severe Asthma
In mouse model of severe asthma, protective resident alveolar macrophages are depleted and replaced by monocyte‐derived populations, particularly a Lyve1loMHCIIhi interstitial macrophage subset enriched for Ccr2/Ccr5 and inflammatory gene programs. Blocking this subset with a dual CCR2/CCR5 antagonist reduces airway inflammation, restores homeostasis ...
Hao Wang +8 more
wiley +1 more source
Development and validation of a multimodal risk prediction model for early COPD progression: a retrospective study integrating clinical, functional, and CT radiomic features. [PDF]
Zhang J +13 more
europepmc +1 more source
This study presents a novel method to analyze the airflow dynamics across the full respiratory cycle in Robin Sequence infants with upper airway obstruction or collapse. It uses 4DCT‐derived airway anatomy and wall movement combined with Computational Fluid Dynamics simulations.
Gautam Jalori +5 more
wiley +1 more source
How to quickly determine whether patients with chronic cough need corticosteroid treatment--construction of a predictive model for corticosteroid-responsive cough in chronic cough. [PDF]
Yi B +7 more
europepmc +1 more source

