Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Fractal analysis of left ventricular trabeculae in hypertensive patients with heart failure: a 3.0 T cardiac magnetic resonance study. [PDF]
Xie Y +8 more
europepmc +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
The effect of high-intensity interval training and moderate-intensity continuous training on cardiorespiratory function in healthy elderly individuals: Systematic review and meta-analysis. [PDF]
Chu R, Li M, Zhu C, Du Y, Wu S.
europepmc +1 more source
On the maximal function associated to the spherical means on the Heisenberg group [PDF]
Sayan Bagchi +3 more
openalex +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Eight weeks equivalent-volume RT and HIIT performed within same session or alternated weekly: comparative effects on physiological adaptations in young adult males. [PDF]
Cheng Y, Ma J, Ye R, Bo S, Li Q.
europepmc +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Motor unit discharge properties of the vastii muscles and their modulation with contraction level depend on the knee-joint angle. [PDF]
Valenčič T +5 more
europepmc +1 more source
Square function/non-tangential maximal function estimates and the\n dirichlet problem for non-symmetric elliptic operators [PDF]
Steve Hofmann +3 more
openalex +1 more source

