Results 91 to 100 of about 2,710,426 (336)

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Complete Closedness of Maximal Monotone Operators [PDF]

open access: yesMathematics of Operations Research, 1983
(This paper is dedicated to the memory of Professor Kwan Chao-Chin, former academic member and director of the Institute of System Science of the Academy of Chinese Sciences.) A maximal monotone operator in Rn is completely closed, i.e., not only closed for points, but also closed for directions. Such a completely closed operator is locally bounded at
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Maximal operator in Dunkl-Fofana spaces

open access: yesAdvances in Pure and Applied Mathematics, 2021
POKOU NAGACY, JUSTIN FEUTO
doaj   +1 more source

Almost Everywhere Convergence of Varying Parameter Setting Cesàro Means of Fourier Series With Respect to Walsh–Kaczmarz System

open access: yesAnnales Mathematicae Silesianae
In this paper, the almost everywhere convergence of Cesàro means of Walsh–Kaczmarz–Fourier series in a varying parameter setting is investigated. In particular, we define subsequence ℕαn,q{{\mathbb{N}}_{{{\alpha }_{n}},q}} of natural numbers and prove ...
Adimasu Anteneh Tilahun
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

The Maximal Regularity of Nonlinear Second-Order Hyperbolic Boundary Differential Equations

open access: yesAxioms
In this paper, we show the maximal regularity of nonlinear second-order hyperbolic boundary differential equations. We aim to show if the given second-order partial differential operator satisfies the specific ellipticity condition; additionally, if ...
Xingyu Liu
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

On the Non-Compactness of Maximal Operators

open access: yesReal Analysis Exchange, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

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