Results 61 to 70 of about 340,092 (283)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Strong Convergence of Generalized Projection Algorithms for Nonlinear Operators

open access: yesAbstract and Applied Analysis, 2009
We establish strong convergence theorems for finding a common element of the zero point set of a maximal monotone operator and the fixed point set of two relatively nonexpansive mappings in a Banach space by using a new hybrid method.
Chakkrid Klin-eam   +2 more
doaj   +1 more source

On localization of the Schr\"odinger maximal operator [PDF]

open access: yes, 2010
In \cite{Lee:2006:schrod-converg}, when the spatial variable $x$ is localized, Lee observed that the Schr\"odinger maximal operator $e^{it\Delta}f(x)$ enjoys certain localization property in $t$ for frequency localized functions. In this note, we give an
Shao, Shuanglin
core  

Maximal operators associated to multiplicative characters [PDF]

open access: yesProceedings of the American Mathematical Society, 2014
7 pages, minor changes to reflect referee ...
Lewko, Allison, Lewko, Mark
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Maximally Alpha-Like Operations [PDF]

open access: yesMusic Theory Online, 2008
Any two Z-related set-classes will map onto one another under 1) TnM or TnMI, or 2) TnM or TnMI in tandem with Morris’s alpha operations, or 3) maximally alpha-like operations, the original contribution of the present paper. This brief “research notes” paper explores the theoretical formulation and analytical application of maximally alpha-like ...
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Almost Everywhere Convergence of Varying Parameter Setting Cesàro Means of Fourier Series With Respect to Walsh–Kaczmarz System

open access: yesAnnales Mathematicae Silesianae
In this paper, the almost everywhere convergence of Cesàro means of Walsh–Kaczmarz–Fourier series in a varying parameter setting is investigated. In particular, we define subsequence ℕαn,q{{\mathbb{N}}_{{{\alpha }_{n}},q}} of natural numbers and prove ...
Adimasu Anteneh Tilahun
doaj   +1 more source

The Maximal Regularity of Nonlinear Second-Order Hyperbolic Boundary Differential Equations

open access: yesAxioms
In this paper, we show the maximal regularity of nonlinear second-order hyperbolic boundary differential equations. We aim to show if the given second-order partial differential operator satisfies the specific ellipticity condition; additionally, if ...
Xingyu Liu
doaj   +1 more source

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