Results 111 to 120 of about 328,728 (289)

Quantitative anatomy of the growing psoas major muscle in the human fetus — an anatomical, digital, and statistical study

Folia Morphologica
BACKGROUND: In the present study we aimed to quantitatively evaluate the growth of the psoas major in human fetuses. MATERIALS AND METHODS: Using anatomical dissection, digital-image analysis (NIS Elements AR 3.0), the volumetric hydrostatic method, and ...
Magdalena Grzonkowska, Michał Szpinda, Michał Kułakowski, Bartłomiej Hankiewicz, Karol Elster, Mariusz Baumgart   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Projection volumes of hyperplane arrangements [PDF]

, 2010
We prove that for any finite real hyperplane arrangement the average projection volumes of the maximal cones is given by the coefficients of the characteristic polynomial of the arrangement. This settles the conjecture of Drton and Klivans that this held
Klivans, Caroline J., Swartz, Ed
core  

Rings whose modules have maximal or minimal projectivity domain

Journal of Pure and Applied Algebra, 2012
This paper was inspired by the definition and study of injectivity domains (as in \textit{A.~N. Alahmadi, M. Alkan} and \textit{S. López-Permouth}, [Glasg. Math. J. 52A, 7-17 (2010; Zbl 1228.16004)] and \textit{N. Er, S. López-Permouth} and \textit{N. Sökmez} [J. Algebra 330, No. 1, 404-417 (2011; Zbl 1227.16004)]).
Holston, Chris, Lopez-Permouth, Sergio R., Ertas, Nil Orhan   +2 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Hybrid Algorithm of Fixed Point for Weak Relatively Nonexpansive Multivalued Mappings and Applications

Abstract and Applied Analysis, 2012
The purpose of this paper is to present the notion of weak relatively nonexpansive multi-valued mapping and to prove the strong convergence theorems of fixed point for weak relatively nonexpansive multivalued mappings in Banach spaces.
Jingling Zhang, Yongfu Su, Qingqing Cheng   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

High breakdown estimators for principal components: the projection-pursuit approach revisited. [PDF]

Li and Chen (J. Amer. Statist. Assoc. 80 (1985) 759) proposed a method for principal components using projection-pursuit techniques. In classical principal components one searches for directions with maximal variance, and their approach consists of ...
Croux, Christophe, Ruiz-Gazen, A
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source