Results 51 to 60 of about 103,524 (321)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Fractional Maximal Functions in Metric Measure Spaces

Analysis and Geometry in Metric Spaces, 2013
We study the mapping properties of fractional maximal operators in Sobolev and Campanato spaces in metric measure spaces. We show that, under certain restrictions on the underlying metric measure space, fractional maximal operators improve the Sobolev ...
Heikkinen Toni, Lehrbäck Juha, Nuutinen Juho, Tuominen Heli   +3 more
doaj   +1 more source

Nonlinear and oblique boundary value problems for the Stokes equations

Electronic Journal of Qualitative Theory of Differential Equations, 2011
In this paper we consider the nonlinear boundary value problem governed by a stationary perturbed Stokes system with mixed boundary conditions (Dirichlet- maximal monotone graph), in a smooth domain.
Hamid Benseridi, Mourad Dilmi
doaj   +1 more source

Non-Autonomous Maximal Regularity in Hilbert Spaces

, 2016
We consider non-autonomous evolutionary problems of the form $u'(t)+A(t)u(t)=f(t)$, $u(0)=u_0,$ on $L^2([0,T];H)$, where $H$ is a Hilbert space.
Dier, Dominik, Zacher, Rico
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Stability of stationary solutions to the three-dimensional Navier-Stokes equations with surface tension

Advances in Nonlinear Analysis, 2023
This article studies the stability of a stationary solution to the three-dimensional Navier-Stokes equations in a bounded domain, where surface tension effects are taken into account.
Watanabe Keiichi
doaj   +1 more source

Global Solvability of Compressible–Incompressible Two-Phase Flows with Phase Transitions in Bounded Domains

Mathematics, 2021
Consider a free boundary problem of compressible-incompressible two-phase flows with surface tension and phase transition in bounded domains Ωt+,Ωt−⊂RN, N≥2, where the domains are separated by a sharp compact interface Γt⊂RN−1.
Keiichi Watanabe
doaj   +1 more source

J. L. Lions’ problem on maximal regularity [PDF]

Archiv der Mathematik, 2017
This is a survey on recent progress concerning maximal regularity of non-autonomous equations governed by time-dependent forms on a Hilbert space. It also contains two new results showing the limits of the theory.
Arendt, Wolfgang, Dier, Dominik, Fackler, Stephan   +2 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Short-time existence of a quasi-stationary fluid–structure interaction problem for plaque growth

Advances in Nonlinear Analysis, 2023
We address a quasi-stationary fluid–structure interaction problem coupled with cell reactions and growth, which comes from the plaque formation during the stage of the atherosclerotic lesion in human arteries.
Abels Helmut, Liu Yadong
doaj   +1 more source