Results 51 to 60 of about 101,397 (323)

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Maximal regularity for non-autonomous Cauchy problems in weighted spaces

Electronic Journal of Differential Equations, 2020
We consider the regularity for the non-autonomous Cauchy problem $$ u'(t) + A(t) u(t) = f(t)\quad (t \in [0, \tau]), \quad u(0) = u_0. $$ The time dependent operator A(t) is associated with (time dependent) sesquilinear forms on a Hilbert space ...
Achache Mahdi, Tebbani Hossni
doaj  

Non-Autonomous Maximal Regularity in Hilbert Spaces

, 2016
We consider non-autonomous evolutionary problems of the form $u'(t)+A(t)u(t)=f(t)$, $u(0)=u_0,$ on $L^2([0,T];H)$, where $H$ is a Hilbert space.
Dier, Dominik, Zacher, Rico
core   +1 more source

Maximal Solutions of Sparse Analysis Regularization [PDF]

Journal of Optimization Theory and Applications, 2018
This paper deals with the non-uniqueness of the solutions of an analysis-Lasso regularization. Most of previous works in this area is concerned with the case where the solution set is a singleton, or to derive guarantees to enforce uniqueness. Our main contribution consists in providing a geometrical interpretation of a solution with a maximal D ...
Barbara, Abdessamad, Jourani, Abderrahim, Vaiter, Samuel   +2 more
openaire   +4 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Fractional Maximal Functions in Metric Measure Spaces

Analysis and Geometry in Metric Spaces, 2013
We study the mapping properties of fractional maximal operators in Sobolev and Campanato spaces in metric measure spaces. We show that, under certain restrictions on the underlying metric measure space, fractional maximal operators improve the Sobolev ...
Heikkinen Toni, Lehrbäck Juha, Nuutinen Juho, Tuominen Heli   +3 more
doaj   +1 more source

Nonlinear and oblique boundary value problems for the Stokes equations

Electronic Journal of Qualitative Theory of Differential Equations, 2011
In this paper we consider the nonlinear boundary value problem governed by a stationary perturbed Stokes system with mixed boundary conditions (Dirichlet- maximal monotone graph), in a smooth domain.
Hamid Benseridi, Mourad Dilmi
doaj   +1 more source

Closedness type regularity conditions for surjectivity results involving the sum of two maximal monotone operators

, 2010
In this note we provide regularity conditions of closedness type which guarantee some surjectivity results concerning the sum of two maximal monotone operators by using representative functions.
A. Moudafi, A. Moudafi, C. Zăalinescu, C. Zălinescu, H. Attouch, H. Attouch, J.-E. Martínez-Legaz, J.M. Borwein, M. Marques Alves, R.I. Boţ, R.I. Boţ, R.I. Boţ, R.T. Rockafellar, Radu Ioan Boţ, S. Bartz, S. Simons, Sorin-Mihai Grad   +16 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source