Results 71 to 80 of about 394,232 (265)
This work presents a possibility to find the optimum solution in the maintenance of high pressure pump systems when the criteria functions are maximal availability and minimal cost maintenance.
Ljubiša Brkić , Božidar V. Krstić
doaj +1 more source
Organoids in pediatric cancer research
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
On the flow peculiarity in network with barrier reachability
The problem of finding maximal flow in networks with barrier reachability is considered. It is shown that existing algorithm for solution this problem can't find solution for all networks. New algorithm is suggested.
N.N. VODOLAZOV
doaj
Maximal solutions to fractional differential equations [PDF]
Summary: When do fractional differential equations have maximal solutions? This note discusses this question in the following way. Firstly, a comparison theorem is formulated that involves fractional differential inequalities. Secondly, a sequence of approximative problems involving polynomials is analyzed, and it is shown that there is a subsequence ...
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On the flow peculiarity in network with barrier reachability
The problem of finding maximal flow in networks with barrier reachability is considered. It is shown that existing algorithm for solution this problem can't find solution for all networks. New algorithm is suggested.
N.N. VODOLAZOV
doaj
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source

