Results 71 to 80 of about 394,232 (265)

Parameters of reliability of high pressure pumps in special purpose vehicles as a basis for maintenance planning

open access: yesVojnotehnički Glasnik, 1999
This work presents a possibility to find the optimum solution in the maintenance of high pressure pump systems when the criteria functions are maximal availability and minimal cost maintenance.
Ljubiša Brkić , Božidar V. Krstić
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On the flow peculiarity in network with barrier reachability

open access: yesВестник Донского государственного технического университета, 2018
The problem of finding maximal flow in networks with barrier reachability is considered. It is shown that existing algorithm for solution this problem can't find solution for all networks. New algorithm is suggested.
N.N. VODOLAZOV
doaj  

Maximal solutions to fractional differential equations [PDF]

open access: yesFractional Differential Calculus, 2015
Summary: When do fractional differential equations have maximal solutions? This note discusses this question in the following way. Firstly, a comparison theorem is formulated that involves fractional differential inequalities. Secondly, a sequence of approximative problems involving polynomials is analyzed, and it is shown that there is a subsequence ...
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

On the flow peculiarity in network with barrier reachability

open access: yesAdvanced Engineering Research, 2008
The problem of finding maximal flow in networks with barrier reachability is considered. It is shown that existing algorithm for solution this problem can't find solution for all networks. New algorithm is suggested.
N.N. VODOLAZOV
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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