Results 81 to 90 of about 607,371 (320)
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A method of determination of an acquisition program in order to maximize the total utility
EIRP Proceedings, 2009 This paper solves in a different way the problem of maximization of the total utility. The author usesthe diofantic equations (equations in integers numbers) and after a decomposing in different cases, he obtains themaximal utility.
Catalin Angelo Ioan
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Journal the Winners, 2014 The aims of this research are to determine the most optimal method for sales forecasting, to show the number of sales forecast on March 2014, and to determine the appropriate and efficient product mix should be produced by PT Astakarya Busanaprima ...
Marcella Marsetiani
doaj +1 more source
TWO-STAGE UTILITY MAXIMIZATION AND IMPORT DEMAND SYSTEMS REVISITED: LIMITATIONS AND AN ALTERNATIVE [PDF]
Two-stage utility maximization theory has been widely used in the literature to estimate import demand for agricultural commodities that are often inputs.
Davis, George C., Jensen, Kimberly L.
core +1 more source
Maximal divisorial ideals and t-maximal ideals
, 2003 We give conditions for a maximal divisorial ideal to be t-maximal and show with examples that, even in a completely integrally closed domain, maximal divisorial ideals need not be t-maximal.
GABELLI, Stefania, ROITMAN MOSHE
openaire +4 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Mas-Colell, Whinston and Green Versus Scitovsky on Profit and Utility Maximization [PDF]
I contrast the theoretical foundation of profit maximization of Mas-Colell, Whinston and Green’s “Microeconomics†against that provided by Scitovsky in a paper of 1943. Whereas Mas-Colell, Whinston and Green try to show that profit maximization can be
Ormazabal Sánchez, Kepa Mirena
core