Results 71 to 80 of about 829,480 (295)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Splenic CD8(+) T cells secrete TGF-beta 1 to exert suppression in mice with anterior chamber-associated immune deviation [PDF]
, 2009 Background CD8(+) regulatory T cells (Treg) have been considered to be involved in a model of ocular-induced tolerance, known as anterior chamber-associated immune deviation (ACAID).
Hao He +13 more
core +1 more source
HeliyonThe normal wiggly probabilistic hesitant fuzzy set (NWPHFS) enhances the conventional probabilistic hesitant fuzzy set (PHFS) by capturing not only explicit probabilistic information but also critical underlying details that may be hidden in the original
Jawad Ali, Dragan Pamucar
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Polynomial Escape Rates via Maximal Large Deviations
Journal of Statistical PhysicsAbstract In this short note, we propose a new and short approach to polynomial escape rates, which can be applied to various open systems with intermittency. The tool of our approach is the maximal large deviations developed in [5].
openaire +2 more sources
Asymptotic results on the maximal deviation of simple random walks
Stochastic Processes and their Applications, 1984 Let \((X_ n)\) be a simple random walk on the set of integers. The authors study the conditional distributions of \({}^+D_ n=\max \{X_ k:0\leq k\leq n\}\) and \(D_ n=\max \{| X_ k|:0\leq k\leq n\}\) on the hypotheses \(X_ n=X_ 0=0\). They obtain explicit formulas as well as asymptotic results for the distribution functions and the moments.
Katzenbeisser, Walter, Panny, Wolfgang
openaire +3 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Maximizing without Borders: Evidence that Maximizing Transcends Decision Domains [PDF]
, 2018 Do maximizers maximize across decision domains? An assumption underlying the literature on maximizing is that the tendency to strive to make the best choice spans domains. The current research provides a direct test of this assumption by examining the
Kokkoris, Michail
core +1 more source
A novel method for single-valued neutrosophic multi-criteria decision making with incomplete weight information [PDF]
Neutrosophic Sets and Systems, 2014 A single-valued neutrosophic set (SVNS) and an interval neutrosophic set (INS) are two instances of a neutrosophic set, which can efficiently deal with uncertain, imprecise, incomplete, and inconsistent information.
Zhiming Zhang, Chong Wu
doaj
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source