Results 121 to 130 of about 12,457,487 (268)
Bi-objective pareto optimization of centric crank-rocker mechanisms
Cogent EngineeringThis paper revisits a classical problem in linkage mechanism design, specifically the design of centric crank-rocker mechanisms for a specified rocker stroke with unit time ratio.
Abdullah F. Al-Dwairi
doaj +1 more source
Maximizing the Benefits of Transitway Investment (Research Brief)
, 2012 This two-page document summarizes Maximizing the Benefits of Transitway Investment (CTS 12-16) which has several insights for integrating economic development and land-use policies with planned transitway investment to increase equity and foster further ...
Fan, Yingling, Tilahun, Nebiyou Y.
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USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Design and Flow Characteristics of a Gravity-Driven Flow Control Valve
MachinesUltra-high-temperature and pressure downhole environments pose challenges for conventional electronic instruments to adapt to high-temperature formations, thereby restricting the application of downhole electronic tool technology in deep and ultra-deep ...
Qing Wang +11 more
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
A Finite-Sample Deviation Bound for Stable Autoregressive Processes
, 2020 In this paper, we study non-asymptotic deviation bounds of the least squares estimator in Gaussian AR(n) processes. By relying on martingale concentration inequalities and a tail-bound for χ2 distributed variables, we provide a concentration bound for ...
González, Rodrigo A., +1 more
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Weighted Wilcoxon-type Smoothly Clipped Absolute Deviation Method [PDF]
, 2011 1 online resource (PDF, 24 pages)Wang, Lan; Li, Runze. (2011). Weighted Wilcoxon-type Smoothly Clipped Absolute Deviation Method.
Li, Runze, Wang, Lan
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