Results 161 to 170 of about 86,732 (286)

Poster 149 Maximum Bite Force Related to Diabetes [PDF]

open access: yesArchives of Physical Medicine and Rehabilitation, 2013
Simone Cecilio Hallak Regalo   +3 more
openaire   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

open access: yesAdvanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang   +16 more
wiley   +1 more source

Analysis of Sample Acquisition Dynamics Using Discrete Element Method [PDF]

open access: yes
The analysis presented in this paper is conducted in the framework of the Ocean Worlds Autonomy Testbed for Exploration Research and Simulation (OceanWATERS) project, currently under development at NASA Ames Research Center. OceanWATERS aims at designing
Case, Jennifer   +3 more
core   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

open access: yesAdvanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore   +20 more
wiley   +1 more source

Bite force and dental implant treatment: a short review

open access: yesMedical Devices: Evidence and Research, 2017
Dennis Flanagan1,2 1Department of Dental Medicine, Implantology LUdeS Foundation, Ricasoli, Malta; 2Private Practice, Willimantic, CT, USA Abstract: Dental implants are placed endosseously, and the bone is the ultimate bearer of the occlusal load ...
Flanagan D
doaj  

Minimum Wages, Labor Market Institutions, and Female Employment and Unemployment: A Cross-Country Analysis [PDF]

open access: yes
This paper estimates the effect of minimum wage regulation in 16 OECD countries, 1970-2008. Our treatment is motivated by Neumark and Wascher's (2004) seminal cross-country study using panel methods to estimate minimum wage effects among teenagers and ...
Addison, John T., Ozturk, Orgul Demet
core  

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

open access: yesAdvanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang   +15 more
wiley   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

open access: yesAdvanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin   +12 more
wiley   +1 more source

STS-36 Space Shuttle mission report [PDF]

open access: yes
The STS-36 Space Shuttle Program Mission Report contains a summary of the vehicle subsystem activities on this thirty-fourth flight of the Space Shuttle and the sixth flight of the OV-104 Orbiter vehicle, Atlantis.
Germany, D. M.   +2 more
core   +1 more source

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