Results 131 to 140 of about 10,268,798 (293)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A New and Fast Approximation Algorithm for Vertex Cover Using a Maximum Independent Set (VCUMI)
Operations Research and Decisions, 2015 The importance of non-deterministic polynomial (NP) problems in real world scenarios has compelled researchers to consider simple ways of finding approximate solutions to these problems in polynomial time.
Imran Khan, Naveed Riaz
doaj
Results in EngineeringInvestigating the maximum independent set in stochastic multilayer graphs provides critical insights into the structural and dynamical properties of complex networks. Recently, stochastic multilayer graphs effectively model the intricate interactions and
Mohammad Mehdi Daliri Khomami +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Constructive-non-constructive approximation and maximum independent set problem
, 1996 We apply in the case of the maximum independent set, a general thought process consisting in integrating an information on the optimal objective value in its instance.
Vangelis Th. Paschos +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Independence and Matchings on Cayley Digraphs of Transformation Semigroups with Fixed Sets
Science and Technology IndonesiaLet $Y$ be a nonempty set of $X$ and denote by $Fix(X,Y)$ a semigroup of full transformations $\alpha$ on $X$ provided that $a\alpha = a$ for all $a\in Y$. Further, let $A$ be a nonempty subset of $Fix(X,Y)$.
Nuttawoot Nupo, Chollawat Pookpienlert
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Maximum Independent Set of a Permutation Graph in K Tracks
, 2014 A maximum weighted independent set of a permutation graph is a maximum subset of noncrossing chords in a matching diagram (i.e., a set \Phi of chords with end-points on two horizontal lines).
M.Sarrafzadeh, D.T.Lee
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source