Results 101 to 110 of about 376,196 (334)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Optimality of estimators for misspecified semi-Markov models [PDF]

, 2006
Suppose we observe a geometrically ergodic semi-Markov process and have a parametric model for the transition distribution of the embedded Markov chain, for the conditional distribution of the inter-arrival times, or for both.
Müller, Ursula U., Schick, Anton, Wefelmeyer, Wolfgang   +2 more
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Evaluating the robustness of targeted maximum likelihood estimators via realistic simulations in nutrition intervention trials. [PDF]

Stat Med, 2022
Li H, Rosete S, Coyle J, Phillips RV, Hejazi NS, Malenica I, Arnold BF, Benjamin-Chung J, Mertens A, Colford JM, van der Laan MJ, Hubbard AE.   +11 more
europepmc   +1 more source

Accuracy of Maximum Likelihood Parameter Estimators for Heston volatility SDE

, 2014
We study approximate maximum likelihood estimators (MLEs) for the parameters of the widely used Heston stock and volatility stochastic differential equations (SDEs). We compute explicit closed form estimators maximizing the discretized log-likelihood of $
Azencott, Robert, Gadhyan, Yutheeka
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Analysis of Marshall–Olkin extended Gumbel type-II distribution under progressive type-II censoring with applications

AIP Advances
In this study, we explore the practical applications of maximum likelihood and Bayesian estimation methods in the context of progressive type-II censoring, focusing specifically on the Marshall–Olkin extended Gumbel type-II distribution.
Dina A. Ramadan, Yusra A. Tashkandy, M. E. Bakr, Oluwafemi Samson Balogun, Mustafa M. Hasaballah   +4 more
doaj   +1 more source

Estimation of Parameters for a Generalized Hypergeometric Distribution Generated by Birth-Death Process

پژوهش‌های ریاضی, 2020
In this paper, we consider a three parametric regularly varying generalized Hypergeometric distribution which have been generated by Birth-Death process for describing phenomena in bioinformatics (Danielian and Astola, 2006).
Davood Farbod
doaj  

On computation of semiparametric maximum likelihood estimators with shape constraints. [PDF]

Biometrics, 2021
Wang Y, Ye ZS, Cao H.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source