Results 71 to 80 of about 373,692 (326)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Non-linear failure rate: A comparison of the Bayesian and frequentist approaches to estimation
ITM Web of Conferences, 2018 In this article, a new generalization of linear failure rate called nonlinear failure rate is developed, analyzed, and applied to a real dataset.
Thach Tien Thanh, Briš Radim
doaj +1 more source
EMPIRICAL LIKELIHOOD ESTIMATORS OF THE LINEAR SIMULTANEOUS EQUATIONS MODEL [PDF]
Information theoretic estimators are specified for a system of linear simultaneous equations, including maximum empirical likelihood, maximum empirical exponential likelihood, and maximum log Euclidean likelihood.
Judge, George G. +2 more
core +1 more source
Optimality of estimators for misspecified semi-Markov models [PDF]
, 2006 Suppose we observe a geometrically ergodic semi-Markov process and have a parametric model for the transition distribution of the embedded Markov chain, for the conditional distribution of the inter-arrival times, or for both.
Müller, Ursula U. +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Mathematics, 2020 This paper attempts to estimate the parameters for the two-parameter Rayleigh distribution based on adaptive Type II progressive hybrid censored data with competing risks. Firstly, the maximum likelihood function and the maximum likelihood estimators are
Shuhan Liu, Wenhao Gui
doaj +1 more source
Moment properties of estimators for an extreme value regression model with type 2 censoring [PDF]
, 1986 An extreme value regression model for grouped data with type 2 censoring is considered. The response variable is taken to have a type 1 ext reme va lue d i s t r i b u t i on for sma l l e s t v a l ue s a nd a s tandar d linear regression model is ...
Haddow, AA, Young, DH
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source