Results 71 to 80 of about 376,196 (334)
A Continuation Technique for Maximum Likelihood Estimators in Biological Models. [PDF]
Bull Math Biol, 2023 Cassidy T.
europepmc +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Robust Estimation and Forecasting of the Capital Asset Pricing Model [PDF]
In this paper, we develop a modified maximum likelihood (MML) estimator for the multiple linear regression model with underlying student t distribution.
Guorui Bian +2 more
core +3 more sources
A Method of Maximum-Likelihood Estimation
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1961 SUMMARY Knowledge of one or more of the parameters in a maximum-likelihood problem sometimes results in a very considerable simplification, the analysis becoming almost trivial. A method of obtaining maximum-likelihood estimates and their asymptotic covariance matrix is given which makes it possible to capitalize on simplifications of ...
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Non-linear failure rate: A comparison of the Bayesian and frequentist approaches to estimation
ITM Web of Conferences, 2018 In this article, a new generalization of linear failure rate called nonlinear failure rate is developed, analyzed, and applied to a real dataset.
Thach Tien Thanh, Briš Radim
doaj +1 more source
Estimating Maximum Likelihood Phylogenies with PhyML [PDF]
, 2009 Our understanding of the origins, the functions and/or the structures of biological sequences strongly depends on our ability to decipher the mechanisms of molecular evolution. These complex processes can be described through the comparison of homologous sequences in a phylogenetic framework.
Guindon, Stéphane +3 more
openaire +3 more sources
EMPIRICAL LIKELIHOOD ESTIMATORS OF THE LINEAR SIMULTANEOUS EQUATIONS MODEL [PDF]
Information theoretic estimators are specified for a system of linear simultaneous equations, including maximum empirical likelihood, maximum empirical exponential likelihood, and maximum log Euclidean likelihood.
Judge, George G. +2 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source