Results 41 to 50 of about 588 (114)

Addressing Small Data Challenges in Biopharmaceutical Development and Manufacturing: A Mini Review of Multi‐Fidelity Techniques

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 6, Page 1465-1480, June 2026.
ABSTRACT The growing demand for biopharmaceutical products reflects their effectiveness in medical treatments. However, developing new biopharmaceuticals remains a major bottleneck, often taking up to a decade before market approval. Machine learning (ML) models have the potential to accelerate this process, but their success depends on access to large
Mohammad Golzarijalal   +2 more
wiley   +1 more source

From Stability to Chaos: A Complete Classification of the Damped Klein‐Gordon Dynamics

open access: yesMathematical Methods in the Applied Sciences, Volume 49, Issue 9, Page 9696-9708, June 2026.
ABSTRACT We investigate the transition between stability and chaos in the damped Klein‐Gordon equation, a fundamental model for wave propagation and energy dissipation. Using semigroup methods and spectral criteria, we derive explicit thresholds that determine when the system exhibits asymptotic stability and when it displays strong chaotic dynamics ...
Carlos Lizama   +2 more
wiley   +1 more source

A Compact Algorithm for Applying Periodic Boundary Conditions in 3D RVE Modeling with Abaqus

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 2, June 2026.
ABSTRACT Periodic boundary conditions (PBCs) are essential in multiscale modeling for computing the effective properties of heterogeneous materials via representative volume elements (RVEs). While several automated solutions have been developed for implementing PBCs in finite element software, many rely on structured node classification and predefined ...
Reza Sadeghpour, Martin Kraska
wiley   +1 more source

On MAP Estimates and Source Conditions for Drift Identification in SDEs

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 2, June 2026.
ABSTRACT We consider the inverse problem of identifying the drift in an stochastic differential equation (SDE) from n$n$ observations of its solution at M+1$M+1$ distinct time points. We derive a corresponding maximum a posteriori (MAP) estimate, we prove differentiability properties as well as a so‐called tangential cone condition for the forward ...
Daniel Tenbrinck   +3 more
wiley   +1 more source

Toward an Efficient Shifted Cholesky QR for Applications in Model Order Reduction Using pyMOR

open access: yesProceedings in Applied Mathematics and Mechanics, Volume 26, Issue 2, June 2026.
ABSTRACT Many model order reduction (MOR) methods rely on the computation of an orthonormal basis of a subspace onto which the large full order model is projected. Numerically, this entails the orthogonalization of a set of vectors. The nature of the MOR process imposes several requirements for the orthogonalization process.
Maximilian Bindhak   +2 more
wiley   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

open access: yesRespirology, Volume 31, Issue 6, Page 561-577, June 2026.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

AI‐Organized Multiscale Battery Modeling: Linking Structure and Property from Quantum to Device Scales

open access: yesSmall Structures, Volume 7, Issue 6, June 2026.
Multiscale modeling of battery systems combines quantum‐mechanical calculations, atomistic simulations, and mesoscale phase‐field approaches to describe processes spanning from reaction energetics to morphology evolution. Establishing consistent links between these scales remains a key challenge, particularly for the transfer of physical descriptors ...
Shoutong Jin   +3 more
wiley   +1 more source

Can AI‐Based Weather Prediction Models Simulate the Butterfly Effect? The Role of Architecture and Implementation

open access: yesJournal of Geophysical Research: Machine Learning and Computation, Volume 3, Issue 3, June 2026.
Abstract Simulations of numerical weather prediction models indicate that the atmosphere possesses an intrinsic limit of predictability. Initial perturbations of tiny amplitude grow quickly in areas of convection and latent heat release, then spread out and move upscale, eventually affecting even the largest planetary scales after about 2 weeks.
T. Selz, G. C. Craig
wiley   +1 more source

Cohomogeneity‐one solitons in Laplacian flow: Local, smoothly‐closing and steady solitons

open access: yesJournal of the London Mathematical Society, Volume 113, Issue 6, June 2026.
Abstract We initiate a systematic study of cohomogeneity‐one solitons in Bryant's Laplacian flow of closed G2$\text{G}_2$‐structures on a 7‐manifold, motivated by the problem of understanding finite‐time singularities of that flow. Here, we focus on solitons with symmetry groups Sp(2)${\rm Sp}(2)$ and SU(3)${\rm SU}(3)$; in both cases, we prove the ...
Mark Haskins, Johannes Nordström
wiley   +1 more source

Stable factorization of the Calderón problem via the Born approximation

open access: yesJournal of the London Mathematical Society, Volume 113, Issue 6, June 2026.
Abstract In this article, we prove the existence of the Born approximation in the context of the radial Calderón problem for Schrödinger operators. The Born approximation naturally appears as the linear component of a factorization of the Calderón problem; we show that the nonlinear part, obtaining the potential from the Born approximation, enjoys ...
Thierry Daudé   +3 more
wiley   +1 more source

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