Results 91 to 100 of about 155,759 (319)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Bioavailability in soils [PDF]

, 2011
The consumption of locally-produced vegetables by humans may be an important exposure pathway for soil contaminants in many urban settings and for agricultural land use.
A Göthberg, A Marin, ACC Plette, AJ Maclean, AL Nolan, AL Nolan, B Buchter, BD Traulsen, BE Davies, BJ Alloway, BS Haslett, BS Shane, C Cobbett, CA Grant, CA Grant, CA Grant, CH Williams, CJ Cappon, CL Luo, CN Geng, CS Hassler, CS Hassler, D Sauerbeck, D Voutsa, DE Salt, DE Salt, DJ Brus, DJ Brus, DJ Brus, DJ Hatch, DM Toro Di, DR Parker, E Brand, E Grill, E Sipter, E Smolders, E Smolders, E Smolders, E Sposito, EA Woolson, EE Cary, EJJ Kalis, F Degryse, F Degryse, F Degryse, F Degryse, F Douay, F Haghiri, FJ Zhao, G Jansson, G Sposito, GA Fleming, GM Thomas, GP Warren, GT Yuran, H Mosbaek, HCH Hahne, IM McKenna, IO Plekhanova, J Ingwersen, JA Ericksen, JC Popelka, JC Tjell, JE Eriksson, JL Hall, JL Hopper, JL Wang, JL Xu, JM Gong, JR Preer, JR Preer, JR Wang, JW Dalenberg, JW Dalenberg, KC Jones, KG Tiller, KR Dunbar, LA Sparrow, LD Tyler, LL Hendrickson, LP Weng, LP Weng, M Helal, M Krauss, M Quaghebeur, M Sobotik, MB McBride, MF Hovmand, MI Mattina, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, MJ McLaughlin, ML Adams, MR Farfel, MTF Wong, NA Maier, NA Maier, OK Vatamaniuk, PD Alexander, PFAM Römkens, PJ Florijn, PJ Florijn, PJ Florijn, PJ Florijn, PMC Antunes, PMC Antunes, PR Anderson, Q Xue, R Hough, R Rellan-Alvarez, R Vogeli-Lange, RA Efroymson, RA Khattak, RH Dowdy, RJ Bowell, RJ Reid, RJM Hudson, RL Chaney, RL Chaney, RL Chaney, RL Hough, RL Hough, RM Harrison, RN Collins, RN Reese, RP Narwal, RT Checkai, S Clemens, S Goldberg, S Goldberg, S Sauvé, S Sauvé, S Tandy, S Tandy, S Thakali, SA Barber, SDW Comber, SE Lorenz, SL Brown, SL McGowen, SN Adams, SN Whiting, SP McGrath, T Adhikari, T Cheng, T Kuboi, T Sterckeman, TL Creger, V Page, W Peijnenburg, W Vries de, W Vries de, WJ Garcia, WP Chen, X Cao, X Du, XP Wang, Y Guo, Y Nakamaru, YT Guo   +164 more
core   +2 more sources

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers [PDF]

, 2012
Background: Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET).
Agostinelli, Claudio, Bergmann, Lothar, Diener, Jürgen, Döring, Claudia, Fanti, Stefano, Gallamini, Andrea, Hansmann, Martin-Leo, Hartmann, Sylvia, Pileri, Stefano, Zinzani, Pier Luigi   +9 more
core   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Early prediction of histopathological response of rectal tumors after one week of preoperative radiochemotherapy using 18 F-FDG PET-CT imaging. A prospective clinical study [PDF]

, 2012
BACKGROUND: Preoperative radiochemotherapy (RCT) is standard in locally advanced rectal cancer (LARC). Initial data suggest that the tumor’s metabolic response, i.e.
Aaron Sulkes, Baruch Brenner, David Groshar, Efraim Idelevich, Hanna Bernstine, Natalia Goldberg, Nir Wasserberg, Noa Gordon, Ofer Purim, Sara Morgenstern, Yulia Kundel   +10 more
core   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging -- design, implementation and application on the example of DCE-MRI

, 2019
Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in DCE MRI/CT, ADC calculations and IVIM modeling in diffusion-weighted MRI and Z-spectra analysis
Abdollahi, Amir, Debus, Charlotte, Floca, Ralf, Ingrisch, Michael, Kompan, Ina, Maier-Hein, Klaus, Nolden, Marco   +6 more
core   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources