Results 61 to 70 of about 2,477,335 (229)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
The ‘Events of May 68’ in Adam Thorpe’s No Telling: a Silent Revolution?
Études Britanniques Contemporaines, 2019 The purpose of this article seeks to interrogate the common presupposition equating revolution to radical change by justifying why the model of linearity and its corollary, rupture, are not the only ways of thinking about the witness-event relationship ...
Alexandre Privat
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Carnets, 2019 The events of May 68, evoked by a Portuguese student at the Lycée Lamartine in Paris. Necessarily fragmented and fragmentary memories.
Paula Mendes Coelho
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Mai 68 ou l’imagination paradoxale
Carnets, 2019 May 68 is a chronotype which occupies a special place in the current imaginary since it means an event that switches continually between excess and lack, where everything takes place and nothing really happens.
Carlos F. Clamote Carreto
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Carnets, 2019 Like Patrick Combes in his book of 1984, La Littérature et le mouvement de mai 68, we willquestion the novels whose central theme or the historical background is the revolt that happened in may 68, in France.We will be particulary interested in three ...
Luís Carlos Pimenta Gonçalves
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source