Results 1 to 10 of about 481 (124)

A Journey Towards Meaning: An Existential Psychobiography of Maya Angelou [PDF]

Europe's Journal of Psychology, 2021
This psychobiography focuses on meaning making in the early life and young adulthood of acclaimed African American author Maya Angelou (1928-2014) through the lens of Frankl’s existential psychology with a specific focus on the tri-dimensional nature of ...
Nadene Harisunker, Carol du Plessis
doaj   +2 more sources

Charactering the interaction between expression quantitative trait loci and Alzheimer's Disease Status [PDF]

Alzheimers Dement
Abstract Background While genetic variation is a major determinant of Alzheimer's Disease (AD) risk, changes in gene expression likely associate with the disease process in complex and poorly understood ways. To address this gap, we examined how genetic variants alter whole‐blood gene expression in the context of AD status within African American (AA ...
Mews M, Mustafa Y, Wheeler N, Gu T, Gomez L, Adams L, Starks T, Cornejo‐Olivas M, Illanes‐Manrique M, Silva C, Feliciano‐Astacio B, Byrd G, Pericak‐Vance M, Haines J, Griswold A, Bush W.   +15 more
europepmc   +2 more sources

Multiomic Analysis of iPSC‐Derived Neural Spheroids Reveals Cell‐Type and Ancestry‐Specific Regulatory Landscapes of Alzheimer's Disease GWAS Genes [PDF]

Alzheimers Dement
Abstract Background Genome‐wide association studies (GWAS) have identified numerous genetic variants associated with Alzheimer's disease (AD), yet their effect sizes vary across populations. This variability stems from ancestry‐dependent differences in the genomic regulatory architecture (GRA), which governs gene expression in a cell‐type‐specific ...
Ramirez A, Nasciben L, Moura S, Coombs L, Robayo M, Rajabli F, DeRosa B, Whitehead P, Adams L, Starks T, Mena P, Illanes‐Manrique M, Tejada S, Byrd G, Cornejo‐Olivas M, Feliciano‐Astacio B, Wang L, Xu W, Jin F, Pericak‐Vance M, Dykxhoorn D, Griswold A, Young J, Vance J.   +23 more
europepmc   +2 more sources

Empowering a Clinical Research Team to Recruit and Retain Hispanic and African American Participants for the DAWN Alzheimer's Research Study [PDF]

Alzheimers Dement
Abstract Background The DAWN study will build a large genomics resource for AD research in individuals with African (Af) and Hispanic/Latino (H/L) ancestry. Clinical Research Coordinators (CRCs) are recruiting 5,000 Af, 4,000 African Americans (AA) and 4,000 H/L participants from the US and ten African sites. Study recruitment is done through community
Starks T, Lloyd S, Terrell K, Fennell C, Hinnant L, Barton K, Witherspoon R, Eley B, Adams L, Douglas M, Duke T, Mena P, McInerney K, Sanchez J, Rodriguez V, Valladares G, Lopez M, Celis K, Chavez J, Cespedes J, Laux R, Kennedy S, Blackshire G, Pryor‐Banks P, Caban‐Holt A, Cuccaro M, Vance J, Haines J, Tosto G, Reitz C, Akinyemi R, Pericak‐Vance M, Byrd G.   +32 more
europepmc   +2 more sources

Imputing Alzheimer's disease phenotype in individuals with mild cognitive impairment for inclusion in gene discovery tests [PDF]

Alzheimers Dement
Abstract Background Genetic association studies of Alzheimer's disease (AD) typically compare cognitively unimpaired (CU) controls to clinically diagnosed AD cases, excluding individuals with mild cognitive impairment (MCI) due to uncertainty about progression.
Martin E, Griswold A, Rajabli F, Gu T, Golightly C, Whitehead P, Hamilton‐Nelson K, Adams L, Sanchez J, Rodriguez V, Mena P, Celis K, Starks T, Silva C, Beecham G, Bush W, Reitz C, McInerney K, Cuccaro M, Vance J, Feliciano‐Astacio B, Byrd G, Haines J, Pericak‐Vance M.   +23 more
europepmc   +2 more sources

Brief Brain Tissue Donation Community Presentations Increase Knowledge, Decrease Misinformation and Improve Brain Donation Acceptability [PDF]

Alzheimers Dement
Abstract Background Black∖African Americans (B∖AA) are underrepresented in Alzheimer's disease (AD) brain tissue donation (BTD) research. Availability of a diverse ancestral collection of brain tissue is critical for functional genomic studies on the pathway to prevention and treatment solutions.
Caban‐Holt A, Cuccaro M, Gregory A, Eley B, Duke T, Chavez J, Jones D, Racy K, Lloyd S, Starks T, Adams L, Haines J, Reitz C, Vance J, Pericak‐Vance M, Byrd G.   +15 more
europepmc   +2 more sources

Peripheral Immune Composition in Alzheimer's Disease: Insights from Multi‐Ancestry RNA‐Sequencing and Cell Deconvolution [PDF]

Alzheimers Dement
Abstract Background Alzheimer's disease (AD) is marked by neuroinflammation and immune system changes, yet the role of peripheral immune cells remains unclear. Immune function varies by ancestry, influencing disease progression and treatment responses. This study applies high‐resolution immune cell deconvolution of whole blood RNA‐seq data from a multi‐
Mustafa Y, Mews M, Gu T, Gomez L, Adams L, Starks T, Cornejo‐Olivas M, Illanes‐Manrique M, Silva‐Vergara C, Feliciano‐Astacio B, Byrd G, Pericak‐Vance M, Haines J, Griswold A, Bush W.   +14 more
europepmc   +2 more sources

Em nome de Maya Angelou

Revista Estudos Feministas, 2019
Este artigo se propõe a reavaliar criticamente a segunda obra autobiográfica de Maya Angelou, Gather together in my name (2004 [1974]). Na representação literária de si, Angelou narra sua jornada de vida como uma jovem mulher negra com um filho sem pai,
Felipe Fanuel Xavier Rodrigues
exaly   +3 more sources

Employment Status, Housing Stability, and Cognitive Health: Socioeconomic Determinants of Alzheimer's Disease and Dementia in Western and Eastern Africa [PDF]

Alzheimers Dement
Abstract Background Socioeconomic factors, including employment status and housing stability, are critical determinants of health outcomes. Economic hardship increases health risks by limiting healthcare access, exacerbating stress, and contributing to poorer mental and physical health.
Scaramutti C, Cai D, Rajabli F, Adams L, Hamilton‐Nelson K, Cuccaro M, Dorfsman D, Akinyemi J, Scott K, Coker M, Akinwande K, Diala S, Whitehead P, Ogunronbi M, Damasceno A, Zaman A, Ayele B, Caban‐Holt A, Ndetei D, Sarfo F, Blanton S, Akpalu A, Consortium A, Alzheimer's Disease Sequencing Project (ADSP), Pericak‐Vance M, Seixas A.   +25 more
europepmc   +2 more sources

Regional Disparities in Educational Attainment and Its Impact on Cognitive Health in Western and Eastern Africa [PDF]

Alzheimers Dement
Abstract Background Education is a crucial social determinant of health, influencing opportunities, socioeconomic status, and health outcomes. Regional disparities in educational attainment and their effects on cognitive health are especially notable in low‐ and middle‐income countries (LMICs), where access to education and healthcare varies widely ...
Scaramutti C, Cai D, Rajabli F, Adams L, Hamilton‐Nelson K, Cuccaro M, Dorfsman D, Akinyemi J, Scott K, Coker M, Akinwande K, Diala S, Whitehead P, Ogunronbi M, Damasceno A, Zaman A, Zewde Y, Ayele B, Caban‐Holt A, Ndetei D, Griswold A, Sarfo F, Blanton S, Akpalu A, Wahab K, McInerney K, Obiako R, Baiyewu O, Mena P, Okubadejo N, Owolabi M, Martinez I, Kunkle B, Vance J, Reitz C, Tosto G, Bush W, Williams S, Kalaria R, Haines J, Ogunniyi A, Byrd G, Consortium A, Alzheimer's Disease Sequencing Project (ADSP), Akinyemi R, Pericak‐Vance M, Seixas A.   +46 more
europepmc   +2 more sources