Results 81 to 90 of about 12,681,973 (219)

Inventory Replenishment and Transshipment for Distributed Autologous Cell Therapy Manufacturing Networks

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Autologous cell therapy (AuCT) manufacturing networks must balance two competing objectives: reducing cost and improving patient access to time‐sensitive therapy. This study compares three AuCT manufacturing network designs: a centralized network with a single manufacturing facility, a coordinated point‐of‐care (POC) network in which POCs can ...
Zhaowei Li, Chelsea C. White III, Kan Wang, Ben Wang   +3 more
wiley   +1 more source

Radial neck fracture fixation by Metaizeau technique in adults: A case series and review of literature

Journal of Orthopaedics, Trauma and Rehabilitation, 2019
Purpose: To evaluate the use of Metaizeau technique in the treatment of radial neck fracture in adults. Method: A total of eight patients were treated with intramedullary pinning (Metaizeau technique) using titanium elastic nails.
Bushu Harna, Ramandeep Singh Saini, Jeetendra Singh Lodhi, Siddharth Sharma   +3 more
doaj   +1 more source

Driven by SDGs, Powered by Human Capital: Managing Emotional Health in SMEs

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines the mediating role of human capital between company emotional capital and managerial perceptions of employees' emotional health, analysing how this relationship is conditioned by the pursuit of specific sustainable development goals (SDGs 3, 4, 5, 8) and perceived institutional pressures in SMEs.
Jesús Barrena‐Martínez, María‐José Foncubierta‐Rodríguez, Dara Hernández‐Roque, María del Carmen Peces Prieto   +3 more
wiley   +1 more source

The Influence of Incongruent Line Extensions on Choice of a Brand's Pre‐Existing Products: The Mediating Role of Curiosity

Journal of Consumer Behaviour, EarlyView.
ABSTRACT Many brands have added highly incongruent products to their product lines, such as Lay's Chicken and Waffles Potato Chips, Blueberry Cheerios, and Carrot Cake Oreos. This paper investigates how highly incongruent products influence the choice of pre‐existing items in the product line.
Brittney Stephenson, Nan Zhao, Cynthia Cryder, Robyn A. LeBoeuf, Stephen M. Nowlis   +4 more
wiley   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Didymozoid Monilicaecum type trematodes in chaetognaths from the Mexican Caribbean Sea Tremátodos didimozoides tipo Monilicaecum en quetognatos del mar caribe mexicano

Revista Mexicana de Biodiversidad, 2007
Analyses of 22,508 holoplanktonic chaetognaths collected at 21 stations were made from four oceanographic campaigns along the coasts of Quintana Roo, Mexico, in 1991 (Caribe I = February; Caribe II = March; Caribe III = May; Caribe IV= August ...
María del Carmen Gómez del Prado-Rosas, José N Álvarez-Cadena, Lourdes Segura-Puertas, Rafael Lamothe-Argumedo   +3 more
doaj  

Angulation osteotomy of ulna for management of missed monteggia fractures and risk factors associated with poor outcomes

Journal of Orthopaedic Reports
Objective: the purpose of this study is to examine the clinical and radiological outcomes, complications and risk factors associated with poor outcomes. Methods: We performed a retrospective chart evaluation in 12 patients (between march 2017–march 2020)
Varun Garg, Aditya K S Gowda, Anil Regmi, Sunny Chaudhary, Surabhi Das, Bishwa Bandhu Niraula, Shivam Bansal, Vivek Singh   +7 more
doaj   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, EarlyView.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Bailey M. Tibben, Maud Maillard, Victoria M. Pratt, Ann M. Moyer, Debbie M. Figueroa, Michelle Whirl‐Carrillo, Andrea Gaedigk, Gabriele Stocco, Matthias Schwab, Kelly E. Caudle, Jun J. Yang   +10 more
wiley   +1 more source

Risk of Bias Associated with Varying Sampling Strategies for External Comparator Cohorts for Single‐Arm Trials: Insights from Aggressive Lymphoma

Clinical Pharmacology &Therapeutics, EarlyView.
Marketing authorizations for oncology drugs are often based on single‐arm trials (SATs), and real‐world data‐based external comparator cohorts (ECCs) are increasingly explored to contextualize results. In retrospective studies, comparators may be identified by time of diagnosis but included based on time of relapse; such sampling strategies can ...
Mikkel Runason Simonsen, Shiva Leisner, Ahmed Ludvigsen Al‐Mashhadi, Laurids Østergaard Poulsen, Matthew Maurer, Lasse Hjort Jakobsen, Tarec Christoffer El‐Galaly   +6 more
wiley   +1 more source