Results 121 to 130 of about 8,284 (184)

Optimization of antibody binding by adjusting thermodynamic stability during the maturation of antibody affinities

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Somatic mutations and antibody clone selection occur in B‐cell hyper‐evolution over extremely brief periods of time. Herein, we developed a technique for antibody screening by immunizing alpacas with antigens and observing antibody sequence transitions over time, a method we named Tracking the Evolution of Antibodies over time.
Yoko Akazawa‐Ogawa, Tomonari Matsuda, Norihiko Kiyose, Nobuo Miyazaki, Tetsuo Fukuta, Motoyasu Adachi, Yuji Ito, Yoshihisa Hagihara   +7 more
wiley   +1 more source

A standard-based taxonomy of features that affect user response to clinical decision support alerts. [PDF]

BMC Med Inform Decis Mak
Liu S, McCoy AB, Sittig DF, Peterson JF, Lasko TA, Wright A.   +5 more
europepmc   +1 more source

Total synthesis and structural characterization of a novel protein scaffold from the snail Biomphalaria glabrata

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Disulfide‐rich miniproteins constitute compact and highly stable scaffolds of growing interest for molecular and structural engineering. Schistosomins are ~80‐residue proteins conserved across gastropods that form a long‐standing orphan family whose structure and biological roles have remained unknown.
Oleg Melnyk, Stéphanie Caby, Armelle Vigouroux, Christine Demanche, Rémi Desmet, Magalie Sénéchal, Benoît Snella, Alexandra Mougel, Céline Boidin‐Wichlacz, Aurélie Parmentier, Ugo Pasco, Sonia Cantel, Solange Moréra, Jérôme Vicogne   +13 more
wiley   +1 more source

Asking the Right Questions: Benchmarking Large Language Models in the Development of Clinical Consultation Templates. [PDF]

Pac Symp Biocomput
McCoy LG, Wu D, Khemani S, Maharaj SK, Pahwa A, Rosengaus L, Giang L, Jee O, Goh E, Haredasht FN, Chopra K, Wu DJ, Conteh A, Ravi V, Weng Y, Li KZ, Shirvani D, Chen JH.   +17 more
europepmc   +1 more source

A cryptic allosteric pocket shapes isoform‐selective inhibition of human malic enzymes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Malic enzymes (ME) regulate central carbon metabolism and cellular redox balance, and the mitochondrial isoform ME2 is frequently upregulated in aggressive cancers to support metabolic flexibility and stress resistance. Isoform‐selective inhibition has remained out of reach because the catalytic machinery is essentially invariant across the ...
Ben A. Krinkel, Yuliana Yosaatmadja, Mark D. Slayton, Anita Krinkel, Jack Copping, Jin Heon Jeon, Joyce Eu, Kerslee Kohagen, Amir Ashoorzadeh, Jeff Smaill, Jack Flanagan, Christopher Walker, Sofia D. Merajver, Kerry Loomes, Christopher J. Squire   +14 more
wiley   +1 more source

Smartwatches and Smart Scales With Body Composition May Interfere With Cardiac Implantable Electronic Devices. [PDF]

Circ Arrhythm Electrophysiol
Hansen N, Sheppard T, McCoy J, Freedman RA, Bayés-Genís A, Steinberg BA, Sanchez B.   +6 more
europepmc   +1 more source

A framework for characterising and capturing the quality of digital interactions and experiences in early childhood education

British Journal of Educational Technology, Volume 57, Issue 5, Page 1299-1319, September 2026.
Abstract Understanding what constitutes quality in digital interactions within Early Childhood Education and Care (ECEC) settings has become paramount in an increasingly technology‐enabled world. This imperative has grown, with diverse ingrained positions about the role of digital technology in ECEC, and limited evidence and guidance to support ...
Steven J. Howard, Kate Lewis, Natalie Day, Lois Peach, Lisa K. Kervin   +4 more
wiley   +1 more source

A Case Report of Non-Neutralizing Acquired Factor V Inhibitor Mimicking Deficiency: Diagnostic Challenges and Therapeutic Implications. [PDF]

Case Rep Hematol
Kalantri S, Pachika P, Balasubramanian S, Alquran B, McCoy M, Sharma V.   +5 more
europepmc   +1 more source

Implementation intentions as an acceptable health behaviour change strategy? Insights from people with lower socio‐economic position in think‐aloud interviews

British Journal of Health Psychology, Volume 31, Issue 3, September 2026.
Abstract Objectives Implementation intentions are simple action plans that may help people with lower socio‐economic position (SEP) to navigate their behaviour in environments that undermine their healthy intentions. Implementation intentions hold potential in being a relatively simple, but remarkably effective behaviour change technique.
Loes van den Bekerom, Laurens C. van Gestel, Satu Koivusaari, Jet Bussemaker, Marieke A. Adriaanse   +4 more
wiley   +1 more source

IFNγ and TNFα optimize salivary gland mesenchymal stromal cells: an alternative to marrow- and adipose-MSCs for radiation xerostomia. [PDF]

Regen Ther
Larsen MC, Gurevic I, Berube L, Vande Loo A, Hanson E, Adam R, Manfrè V, Parker M, Paz C, Galipeau J, Kimple RJ, Blitzer G, McCoy SS.   +12 more
europepmc   +1 more source